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Compound combined medicament for treating ulcerative colitis and preparation method of compound combined medicament

A technology for ulcerative colitis and drugs, which is applied in the direction of drug combinations, medical preparations containing active ingredients, and pharmaceutical formulas, etc., can solve problems that cannot be popularized and applied, improve the general shape and mucosal histopathology, and increase drug stability permanent, easy-to-operate effect

Active Publication Date: 2015-06-24
JIANGSU PROVINCIAL HOSPITAL OF TCM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, the main treatment for refractory ulcerative colitis is to invigorate the spleen and kidney, clear the intestines and relieve ulcers. By improving the hormone resistance of patients with refractory ulcerative colitis, there is currently a lack of compound drugs with the best drug ratio in clinical practice. Not yet available for promotion

Method used

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  • Compound combined medicament for treating ulcerative colitis and preparation method of compound combined medicament
  • Compound combined medicament for treating ulcerative colitis and preparation method of compound combined medicament
  • Compound combined medicament for treating ulcerative colitis and preparation method of compound combined medicament

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] A compound combination medicine for treating ulcerative colitis, which is made of the following components in parts by weight: 15 parts of raw Astragalus membranaceus, 10 parts of fried Atractylodes macrocephala, 15 parts of psoraleae, 10 parts of Yizhiren, 10 parts of Scutellaria baicalensis, 3 parts of Coptis chinensis 10 parts of Burnet, 6 parts of Woody Fragrance, 3 parts of Zhi Licorice. A total of nine herbs.

[0023] Weigh the above nine herbs by weight, add 10 times the weight of water and decoct 3 times (the first time soaking for 60 minutes), each time for 1.5 hours, filter, combine the filtrate, concentrate under reduced pressure to an appropriate amount, and straight tube high-speed centrifugation Centrifuge in a machine, add water to the specified amount, mix evenly, sub-package, and sterilize with circulating steam for 45 minutes to obtain a liquid preparation.

Embodiment 2

[0025] A compound combination medicine for treating ulcerative colitis, which is made of the following components in parts by weight: 20 parts of raw Astragalus membranaceus, 25 parts of fried Atractylodes macrocephala, 10 parts of psoraleae, 5 parts of Yizhiren, 15 parts of Scutellaria baicalensis, 3 parts of coptis, 15 parts of Burnet, 3 parts of woody fragrance, 3 parts of roasted licorice. A total of nine herbs.

[0026] Weigh the above nine herbs according to parts by weight, add 15 times the amount of water to soak for 45 minutes, decoct twice for 1 hour each time, filter, combine the filtrate, concentrate the filtrate under reduced pressure to an appropriate amount, remove the precipitate by centrifugation or filtration, and then reduce Press and condense to a thick paste with a relative density of 1.20-1.35 (60°C), add appropriate amount of microcrystalline cellulose and dextrin, make soft materials, make granules, vacuum-dry, sieve whole grains, pack capsules, and obt...

Embodiment 3

[0028] A compound combination medicine for treating ulcerative colitis, which is made of the following components in parts by weight: 30 parts of raw Astragalus membranaceus, 5 parts of fried Atractylodes macrocephala, 10 parts of psoraleae, 20 parts of Yizhiren, 5 parts of Scutellaria baicalensis, 10 parts of coptis, 10 parts of Burnet, 10 parts of woody fragrance, 1 part of roasted licorice. A total of nine herbs.

[0029] Weigh the above nine herbs according to parts by weight, add 5 times the weight of water, soak for 60 minutes, decoct 3 times, 2.5 hours each time, combine the filtrate, concentrate under reduced pressure to an appropriate amount, centrifuge or filter to remove the precipitate, and then concentrate under reduced pressure to For a thick paste with a relative density of 1.20-1.35 (60°C), add lactose or cornstarch, and magnesium stearate if necessary, vacuum-dry, granulate, and compress into tablets to obtain tablets.

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Abstract

The invention discloses a compound combined medicament for treating ulcerative colitis. The compound combined medicament is prepared from the following components in parts by weight: 5-40 parts of raw milkvetch root, 5-30 parts of fried largehead atractylodes rhizome, 5-40 parts of malaytea scurfpea fruit, 5-30 parts of sharpleaf galangal fruit, 5-30 parts of baical skullcap root, 1-15 parts of coptis root, 5-30 parts of garden burnet root, 3-20 parts of costus root and 1-15 parts of fried liquoric root. The invention also discloses a preparation method of the compound combined medicament for treating ulcerative colitis. The invention provides an effective therapeutic medicament for clinically treating a refractory disease namely ulcerative colitis, and the medicament is economical and practical and has a broad clinical application prospect; and the preparation method of the medicament is simple, quick, efficient, and easy to operate, and the medicament is prepared into tablets, capsules and granules to facilitate taking.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a compound medicine for treating ulcerative colitis and a preparation method thereof. Background technique [0002] Ulcerative colitis (UC) is a chronic non-specific inflammation that mainly involves the rectum and colonic mucosa, and belongs to the category of inflammatory bowel disease (IBD). Seriously affect health and quality of life. Because its etiology is still unclear, difficult to cure, easy to relapse and cancerous, it has been listed as a difficult disease by the World Health Organization (WHO). In Asia, the annual incidence rate of UC is 1.0 / 100,000 to 2.0 / 100,000, and the prevalence rate is 4.0 / 100,000 to 44.3 / 100,000. It is estimated that the prevalence of UC in my country is 11.6 / 100,000. In recent years, with the improvement of living standards, changes in diet structure, living habits, environmental changes, and continuous prog...

Claims

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Application Information

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IPC IPC(8): A61K36/9062A61P1/04
Inventor 沈洪叶柏朱磊郑凯
Owner JIANGSU PROVINCIAL HOSPITAL OF TCM
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