Use of polydatin in the preparation of antiarrhythmic products

A technology of polydipside and its use is applied in the field of use of polydipside in the preparation of antiarrhythmic products, which can solve the problems of fast reperfusion, ventricular arrhythmia, severe ischemia and the like, and achieve the effect of low price.

Active Publication Date: 2018-09-11
SHENZHEN UNIV
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Problems solved by technology

2) The number of ischemic myocardium is large, the degree of ischemia is severe, and the rate of reperfusion is fast, so the incidence of arrhythmia is high
[0007] Antiarrhythmic drugs currently used and developed clinically can be classified into four categories according to their effects on myocardial electrophysiology and their mechanism of action: Class I is a sodium channel blocker, but it can cause severe sinus bradycardia, Side effects such as atrioventricular block and QRS widening induced new torsades de pointes

Method used

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  • Use of polydatin in the preparation of antiarrhythmic products
  • Use of polydatin in the preparation of antiarrhythmic products

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Experimental program
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Embodiment Construction

[0028] 1. Materials and Methods

[0029] 1.1 Materials

[0030] 1) Reagent Polydatin used in the present invention is provided by Shenzhen Haiwang Pharmaceutical Company,

[0031] The specific extraction method is as follows:

[0032] 100g rhizome of Polygonum cuspidatum, properly crushed, extracted by percolation with 800ml ethanol, filtered, concentrated under reduced pressure (50°C, 0.07-0.1Mpa) to a final volume of 50ml, added 100ml water, and extracted 3 times with 200ml acetic acid ethanol, the extract was decompressed Concentrate (50°C, 0.07-0.1Mpa) to 150ml, stir the polyamide powder, evaporate the solvent under reduced pressure, and use it as a loading sample for later use.

[0033] The loaded sample is loaded on a spare polyamide column (about 600ml column) by dry method, and then chromatographically eluted with 1000ml water and 3000ml30% ethanol water as the mobile phase at a flow rate of 600ml / hr, collected and washed with 30% ethanol The effluent was removed, a...

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Abstract

The invention provides an application of polydatin to preparation of an anti-arrhythmic product and relates to the applications of the polydatin which is a polygonum cuspidatum extract. In-vitro study and experiment results show that the polydatin has a powerful protection function on arrhythmia, and therefore the polydatin can be applied to the preparation of anti-arrhythmic products. According to the application, the polydatin shortens the action potential duration (APD) of myocardial cells by increasing the density of an instant transient outward potassium current (Ito), QT interval prolongation is restrained, and therefore the anti-arrhythmic function is achieved.

Description

technical field [0001] The present invention relates to the clinical application of active ingredients of Chinese medicinal materials, and mainly relates to the application of a traditional Chinese medicine extract, i.e. piceid, polydatin, in the preparation of anti-arrhythmic products, especially in the preparation of anti-arrhythmic products caused by myocardial infarction. use. Background technique [0002] 1. Arrhythmia [0003] Arrhythmia is due to abnormal sinoatrial node excitation or excitation outside the sinoatrial node, the conduction of the excitation is slow, blocked or conducted through abnormal channels, that is, the origin of cardiac activity and (or) conduction disorders lead to the frequency and (or) heart beat ) abnormal rhythm. Arrhythmia is an important group of diseases in cardiovascular diseases. It can occur alone or be associated with cardiovascular disease. It can cause sudden death due to sudden onset, and it can also continue to involve the he...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7034A61P9/06
Inventor 董鸣刘杰刘文娟邓建新
Owner SHENZHEN UNIV
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