Three-layer integrated composite support and manufacturing method thereof

Abstract

The invention discloses a three-layer integrated composite stent and a transplanting method thereof. The highly bionic stent comprises a cartilage layer, an intermediate transition layer, and a bone layer which are sequentially stacked from top to bottom, wherein the cartilage layer is prepared from low-concentration chitosan; the intermediate layer is prepared from a mixture of high-concentration chitosan and metallic titanium; the bone layer is prepared from a metallic 'titanium cage' and an autologous bone. The transplanting method comprises the following steps: using chitosan and the metallic 'titanium cage' as the stent materials to manufacture the three-layer integrated composite stent; partially inoculating autologous chondrocytes to the cartilage part of the stent; performing in-vitro culture; transplanting the tissue block to the position in front of a defected part, and inoculating the autologous bone to the bone part of the stent; and embedding the stent to the articular cartilage defect zone through a press fit principle according to an autologous bone-cartilage transplantation method at last. According to the three-layer integrated composite stent and the transplanting method thereof, disclosed by the invention, the intermediate layer has the function of stopping the chondrocytes from growing downwards; the 'titanium cage' part has the function of fixing the autologous bone, and promoting the coalescing function for the autologous bone and the host bone, so as to treat the cartilage injury.

Description

technical field [0001] The invention relates to a composite bracket and a manufacturing method thereof, in particular to a three-layer integrated composite bracket and a manufacturing method thereof, belonging to the field of articular cartilage defect repair. Background technique [0002] Traumatic articular cartilage injury and cartilage defect caused by osteoarthritis are common clinical diseases, and their effective treatment has always been a clinical problem to be solved urgently. In recent years, many scholars at home and abroad have carried out research work on the use of tissue engineered cartilage to repair cartilage defects. Based on the success of a large number of basic research and animal experiments, European and American countries have achieved initial clinical success. [0003] Although the application of tissue engineered cartilage to repair cartilage defects has achieved promising results, there are still many problems to be solved in this field. Especia...

AI Technical Summary

Problems solved by technology

It plays a role in blocking the downward growth of chondrocytes, and by implanting autologous bone in the "titanium cage" to replace the process of implanting osteoblasts from the previous bone layer, it solves the problem that it is difficult to plant two kinds of cells on the same scaffold, thus To achieve the purpose of treating cartilage damage

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