Animal-derived nerve scaffold and preparation method thereof

An animal-derived, nerve-based technology, applied in the field of nerve repair, can solve problems such as insufficient autologous nerve supply, impaired donor site function, and nerve damage

Active Publication Date: 2015-04-29
DONGGUAN REVOLUTION PROD DESIGN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In order to overcome the deficiencies of the prior art, the present invention provides an animal-derived nerve scaffold and its preparation method. The nerve scaffold is derived from animals, which solves the problem of insufficient supply of autologous nerves, and also solves the problem that autologous nerve transplantation will inevitably cause new nerves. Injury, a problem that leads to impaired function of the donor site, has profound implications for nerve repair

Method used

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  • Animal-derived nerve scaffold and preparation method thereof

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Effect test

Embodiment 1

[0020] Embodiment 1: The preparation method of the animal-derived nerve scaffold comprises the following steps:

[0021] 1) Animal-derived film material powder: animal-derived blood vessels are freeze-dried, sterilized and ground into powder to obtain animal-derived film material powder;

[0022] 2) Prepare the scaffold: Dissolve the animal-derived film material powder completely in dichloromethane, and disperse it evenly by ultrasonic to obtain a slurry, which is transferred into the mold cavity of the film-making mold, and horizontal and vertical magnesium alloys are placed in the mold cavity along the molding direction of the bracket. The zinc alloy wire is immersed in the slurry, the solvent is naturally volatilized and dried, vacuumized for 48 hours, and dried at low temperature, and the dried scaffold film material wraps the magnesium wire to obtain the animal-derived nerve scaffold.

Embodiment 2

[0023] Embodiment 2: The preparation method of the animal-derived nerve scaffold comprises the following steps:

[0024] 1) Animal-derived film material powder: animal-derived nerve tubes are freeze-dried, sterilized and ground into powder to obtain animal-derived film material powder;

[0025] 2) Prepare the scaffold: Dissolve the animal-source film material powder completely in dichloromethane, and disperse it evenly by ultrasonic to obtain a slurry, which is transferred into the mold cavity of the film-making mold, and the horizontal and vertical movable membranes are placed in the mold cavity along the molding direction of the bracket. To degrade the metal wire, immerse the degradable metal wire in the slurry, let the solvent volatilize and dry naturally, vacuumize for 48 hours, and dry at low temperature. The dried stent film material wraps the magnesium wire to obtain the animal-derived nerve stent.

Embodiment 3

[0026] Embodiment 3: The preparation method of the animal-derived nerve scaffold comprises the following steps:

[0027] 1) Animal-derived film material powder: animal-source intestinal tract is freeze-dried, sterilized and ground into powder to obtain animal-source film material powder;

[0028] 2) Prepare the scaffold: Dissolve the animal-source film material powder completely in dichloromethane, and disperse it evenly by ultrasonic to obtain a slurry, which is transferred into the mold cavity of the film-making mold, and the horizontal and vertical movable membranes are placed in the mold cavity along the molding direction of the bracket. To degrade the metal wire, immerse the degradable metal wire in the slurry, let the solvent volatilize and dry naturally, vacuumize for 48 hours, and dry at low temperature. The dried stent film material wraps the magnesium wire to obtain the animal-derived nerve stent.

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Abstract

The invention provides an animal-derived nerve scaffold which comprises a scaffold membrane material and degradable metal wires wrapped in the scaffold membrane material, wherein main components of the scaffold membrane material are animal-derived blood vessels, lymphatic vessels, neural tubes or intestinal tracts. The animal-derived nerve scaffold is derived from animals, so that the problem of short supply of autologous nerves is solved, the problem of donor site function damage caused by new nerve injury inevitably caused by autologous neural transplantation is also solved, and the nerve scaffold has far-reaching significance for nerve repair.

Description

technical field [0001] The invention relates to the technical field of nerve restoration, in particular to an animal-derived nerve scaffold and a preparation method thereof. Background technique [0002] Peripheral nerve damage or rupture caused by various trauma causes the decrease or loss of sensory and motor functions of the injured. Severe peripheral nerve damage often results in paralysis or permanent disability. Peripheral nerve injury has a high incidence rate in my country. According to statistics, among trauma patients, limb nerve injury accounts for about 10% of the total number of trauma, and about 60% of firearm injury fractures are combined with nerve injury. Therefore, it is necessary to find an ideal treatment method for peripheral nerve injury. For peripheral nerve rupture injuries, if the rupture gap is large, bridging and transplantation of the gap is necessary to regenerate and repair the ruptured peripheral nerve. [0003] At present, commonly used gra...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/36A61L27/50A61L27/04
CPCA61L27/04A61L27/36A61L27/50
Inventor 李扬德
Owner DONGGUAN REVOLUTION PROD DESIGN
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