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Application of bacteroides thetaiotaomicron in treating or preventing rheumatoid arthritis or related diseases thereof

A polymorphic Bacteroides, rheumatoid technology, applied in the field of microbiology, can solve the problem of no effective treatment or cure

Inactive Publication Date: 2015-04-29
BGI SHENZHEN CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Since the etiology and pathogenesis are not yet fully understood, although some progress has been made in the treatment of RA, it is still in the stage of controlling or relieving symptoms, and there is no effective treatment or cure.

Method used

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  • Application of bacteroides thetaiotaomicron in treating or preventing rheumatoid arthritis or related diseases thereof
  • Application of bacteroides thetaiotaomicron in treating or preventing rheumatoid arthritis or related diseases thereof
  • Application of bacteroides thetaiotaomicron in treating or preventing rheumatoid arthritis or related diseases thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0069] Example 1 Determine the beneficial bacteria for the treatment or prevention of rheumatoid arthritis

[0070] 1.1 Sample collection and DNA extraction

[0071] A total of 212 samples of feces, tartar and saliva were collected from Peking Union Medical College Hospital. The sample information is shown in Table 1. Among them, they were divided into training group and test group. The training group included 157 volunteers, of which 77 were untreated RA cases and 80 were healthy individuals (controls). In the test group, 34 volunteers formed 17 "case-healthy" pairs, of which 8 were related by blood and the other 9 were not related by blood; the other 21 volunteers were treated with DMARD (disease-modifying antirheumatic drugs) for RA cases.

[0072] Feces samples were collected and transported frozen and quickly transferred to -80°C for DNA extraction (refer to Qin, J. et al. A metagenome-wide association study of gut microbiota in type 2diabetes. Nature 490, 55–60 (2012))...

Embodiment 2

[0098] Embodiment 2 animal experiment verification

[0099] In order to verify that Example 1 determines the beneficial bacteria for the treatment or prevention of rheumatoid arthritis in Table 2, Table 3, Table 4, and Table 5, the inventor conducts animal experiments for each bacterial species, and uses the available bacterial strain verification of the bacterial species its efficacy.

[0100] experimental method

[0101] 1. Modeling and administration

[0102] 6-8 weeks old SPF (Specific pathogen free) grade male DBA / 1J mice were purchased from the Shanghai Experimental Animal Center of the Chinese Academy of Sciences and raised in the IVC (individual ventilated cage) mouse cage system (purchased from Suzhou Fengshi Experimental Animal Equipment Co., Ltd. ), the indoor temperature was kept at 22-24°C, the humidity was 40%-60%, the light was 12 hours a day, and food and water were free to eat. After 2 weeks of adaptive feeding, they were randomly divided into 5 groups (mod...

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Abstract

The invention provides application of bacteroides thetaiotaomicron in treating or preventing rheumatoid arthritis or related diseases thereof, and further provides a pharmaceutical composition, a medicine, a food and feed containing the bacteroides thetaiotaomicron. Applied to animals, the bacteroides thetaiotaomicron can be used for effectively developing an anti-inflammatory efficacy, so that the symptom of redness and swelling of joint is effectively improved and the symptom of arthritis is remarkably relieved; and the bacteroides thetaiotaomicron can be effectively used for treating or preventing rheumatoid arthritis or related diseases thereof.

Description

technical field [0001] The present invention relates to the field of microbiology, in particular to the use of Bacteroides polymorpha in treating or preventing rheumatoid arthritis or related diseases, and also to pharmaceutical compositions, medicines, foods and feeds containing Bacteroides polymorpha. Background technique [0002] Rheumatoid arthritis (RA), referred to as rheumatoid, is a systemic autoimmune disease that mainly involves joint synovium, followed by connective tissue such as serosa, heart, lung, blood vessels, and nerves. In the acute stage, inflammation mainly manifests as synovial angioedema and synovitis. If not diagnosed and treated in time, the acute inflammatory response subsides, the exudate is gradually absorbed, pannus forms in the synovium, and synovial cells proliferate significantly. Then it causes the destruction of articular cartilage, bone tissue inflammation, necrosis and hyperplasia of fibrous connective tissue. Then calcification occurs, f...

Claims

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Application Information

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IPC IPC(8): A61K35/74A61P19/02A61P29/00A23L1/30A23K1/16
Inventor 冯强张东亚贾慧珏刘传肖亮王俊
Owner BGI SHENZHEN CO LTD
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