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A microfluidic unit for improved detection specificity

A microfluidic unit and specific technology, applied in the field of sensors, can solve problems such as the inability to realize single or small cells and small microfluidics, and achieve the effect of improving detection efficiency and quality, improving sensitivity and specificity, and reducing bacterial culture links.

Active Publication Date: 2017-05-31
THE FIRST AFFILIATED HOSPITAL OF THIRD MILITARY MEDICAL UNIVERSITY OF PLA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In view of this, the object of the present invention is to provide a microfluidic unit for sub-THz nano-biosensors to solve the problem in the prior art that a single or a small number of cells cannot normally pass through a small microfluidic, and provide the following technical solutions:

Method used

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  • A microfluidic unit for improved detection specificity
  • A microfluidic unit for improved detection specificity
  • A microfluidic unit for improved detection specificity

Examples

Experimental program
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Effect test

Embodiment 1

[0026] Such as Figure 1 to Figure 3 As shown, in this embodiment, a microfluidic unit for improving detection specificity includes at least one microfluidic body 1 in a tubular structure, and a positive pressure generating device 2 is provided at the cell inlet end of the microfluidic body, and the microfluidic body A negative pressure generator 3 is provided at the cell outlet. The positive pressure generating device generates positive pressure, and the negative pressure generating device generates negative pressure. Under the joint action of positive and negative pressure, cells in the cell solution are pushed into the microfluidic body 1 to realize detection.

[0027] In this implementation, a microfluidic unit with a pipe diameter of 4-6 μm, preferably 5 μm, is used to increase positive pressure and negative pressure generating devices at both ends of the microfluidic body, so that sufficient negative pressure can be generated in the microfluidic body to allow the Only a...

Embodiment 2

[0034] Such as Figure 4 As shown, the difference between embodiment 2 and embodiment 1 is that the microfluidic body 1 is set as a Y-shaped structure, that is, the microfluidic body is combined into a unified channel before the negative pressure generating device 3 is connected, so that multiple microfluidic bodies 1 The centralized processing of the pipes forms a negative pressure structure, and the cell solution is more likely to enter the microfluidic body 1, and the effect is better. Other structures are the same as in Embodiment 1, and will not be described here again.

Embodiment 3

[0036] Such as Figure 5 For Example 3, the difference from Example 1 is that the microfluidic body 1 is set in a U-shaped structure, which can increase the length of the microfluidic body, and it is easier to disperse a certain number of cells to be tested, which is conducive to the entry of the cell solution Microfluidic body 1, the effect is better. Other structures are the same as in Embodiment 1, and will not be described here again.

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Abstract

The invention discloses a microfluidic unit for improving testing specificity, and belongs to the technical field of sensors. The microfluidic unit at least comprises a microfluidic body which is of a tubular structure. A positive pressure generating device is arranged at the cell inlet end of the microfluidic body, and a negative pressure generating device is arranged at the cell outlet end of the microfluidic body. Due to the facts that the microfluidic unit with the proper tube diameter is arranged, and the positive pressure generating device and the negative pressure generating device are added to the two ends of the microfluidic body, enough negative pressure can be generated in the microfluidic body, and only a single or a few cells to be tested can pass through the microfluidic unit, testing specificity is effectively improved, the purpose that bacteria with different characters are directly tested in a qualitative and quantitative mode through a sub-THz sensing technology is achieved, the number of steps of bacterial culture is reduced, and testing efficiency and quality are improved.

Description

technical field [0001] The invention belongs to the technical field of sensors, and in particular relates to a microfluidic unit for a sub-THz nanometer biosensor. Background technique [0002] Microfluidics is a technology developed on the basis of microelectronics, micromechanics, bioengineering and nanotechnology, which can control, operate and detect complex fluids at a microscopic scale. It can operate continuously, accurately control reaction conditions, use less, save costs, and can be integrated and mass-produced. This technology is becoming more and more mature, and more and more are applied in biomedicine, and it is developing from the stage of experimental research to commercialization. For example, the application of microfluidic biochips in the screening of rare cells, the extraction and purification of information ribonucleic acid, gene sequencing, single cell analysis, protein crystallization, drug detection, etc. [0003] Terahertz nanobiosensors use Terahe...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N21/01
Inventor 黄庆府伟灵杨翔李永川
Owner THE FIRST AFFILIATED HOSPITAL OF THIRD MILITARY MEDICAL UNIVERSITY OF PLA
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