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Hemostasis bandage capable of absorbing micropore vacuum polysaccharides and manufacturing method thereof

A polysaccharide and hemostatic patch technology, applied in the field of medicinal chemistry, can solve the problems of poor biocompatibility of the hemostatic patch, prone to allergic reactions, narrow application range, etc., achieve good adhesion, wide range of bleeding wounds, and prevent infection Effect

Inactive Publication Date: 2015-03-11
史跃
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to provide an absorbable microporous vacuum polysaccharide hemostatic patch and its preparation method, mainly aiming at the problems of poor biocompatibility, poor adhesion, prone to allergic reactions, narrow application range and cumbersome operation of the current hemostatic patch , overcoming the deficiencies in the current existing technology

Method used

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Effect test

preparation example Construction

[0026] A method for preparing an absorbable microporous vacuum polysaccharide hemostatic patch, comprising the following steps: step 1 of preparing absorbable microporous vacuum polysaccharide hemostatic particles, and step 2 of preparing a hemostatic patch.

[0027] Step 1 Preparation of absorbable microporous vacuum polysaccharide hemostatic particles:

[0028] Step 1-1 Gelatinization treatment: using plant starch as raw material, use an extruder to extrude the plant starch. During the extrusion process, the extrusion friction of the extruder generates heat, and the starch absorbs heat and is subjected to strong shearing force , the hydrogen bonds between the molecular chains of starch molecules are broken, and the molecular chains move, causing partial disintegration of starch granules and gelatinization. The starch treated by this method has a degree of gelatinization of more than 90%. The traditional heating gelatinization rate is only 80-85%, and the operation is conven...

Embodiment 1

[0035] Step 1 Preparation of absorbable microporous vacuum polysaccharide hemostatic particles:

[0036] Step 1-1 Gelatinization treatment: using plant starch as raw material, use an extruder to extrude the plant starch. During the extrusion process, the extrusion friction of the extruder generates heat, and the starch absorbs heat and is subjected to strong shearing force , the hydrogen bonds between the molecular chains of starch molecules are broken, and the molecular chains move, causing partial disintegration of starch granules and gelatinization. The starch treated by this method has a degree of gelatinization of more than 90%. The traditional heating gelatinization rate is only 80-85%, and the operation is convenient, the equipment is simple, the heating is uniform, and the industrialization is easy to produce;

[0037] Step 1-2 Emulsification treatment: the starch gelatinized product obtained in step 1-1 is emulsified by an emulsifier to form a water-in-oil W / O soluti...

Embodiment 2

[0043] Step 1 Preparation of absorbable microporous vacuum polysaccharide hemostatic particles:

[0044] Step 1-1 Gelatinization treatment: using plant starch as raw material, use an extruder to extrude the plant starch. During the extrusion process, the extrusion friction of the extruder generates heat, and the starch absorbs heat and is subjected to strong shearing force , the hydrogen bonds between the molecular chains of starch molecules are broken, and the molecular chains move, causing partial disintegration of starch granules and gelatinization. The starch treated by this method has a degree of gelatinization of more than 90%. The traditional heating gelatinization rate is only 80-85%, and the operation is convenient, the equipment is simple, the heating is uniform, and the industrialization is easy to produce;

[0045] Step 1-2 Emulsification treatment: the starch gelatinized product obtained in step 1-1 is emulsified by an emulsifier to form a water-in-oil W / O soluti...

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Abstract

The invention discloses a hemostasis bandage capable of absorbing micropore vacuum polysaccharides and a manufacturing method of the hemostasis bandage. The hemostasis bandage capable of absorbing the micropore vacuum polysaccharides comprises non-woven fabric; the edge of the non-woven fabric is provided with medical pressure-sensitive adhesives; a gelatin sponge is pasted to the surface of the non-woven fabric; the surface of the gelatin sponge is covered with release paper; grooves are formed in the surface of the gelatin sponge; hemostasis particles capable of absorbing the micropore vacuum polysaccharides are inlaid into the grooves; the hemostasis particles capable of absorbing the micropore vacuum polysaccharides come from plant starch; and the hemostasis bandage capable of absorbing the micropore vacuum polysaccharides is obtained through a series of manufacturing steps. The hemostasis bandage and the manufacturing method have the advantages that the hemostasis bandage capable of absorbing the micropore vacuum polysaccharides is convenient to use, high in stability, high in self absorbing capacity, capable of rapidly sealing wounds, free of adhesions with the surfaces of the wounds, suitable for wide hemorrhage wound surface scope and free of limitation of using environments; the hemorrhage of the surfaces of the wounds is effectively controlled; the effect of preventing infections is achieved; and the hemostasis bandage and the manufacturing method are of an important significance in rescuing lives of the wounded.

Description

technical field [0001] The invention relates to the field of medicinal chemistry, in particular to an absorbable microporous vacuum polysaccharide hemostatic patch and a preparation method thereof. Background technique [0002] In order to improve the treatment level of war wounds under the conditions of modern high-tech local wars, all countries pay special attention to the development of first aid technology for war wounds, and hemostasis is the most urgent first aid for war wounds. Due to the special nature of war, temporarily covering the bleeding wound with a hemostatic dressing is the most effective way to treat war injuries in the early stage. Currently, the commonly used local hemostatic materials include hemostatic gauze, hemostatic fiber, and hemostatic bandage. Because these hemostatic materials are not easy to be absorbed by the tissue, take a long time to stop bleeding, easily adhere to the wound, and easily cause wound infection, etc., so the hemostatic plaste...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F13/02A61L15/28A61L15/44A61L15/42
CPCA61L15/225A61L15/425A61L15/44A61F13/00063A61F13/0286A61F13/01012
Inventor 史跃王颖朱卉琪
Owner 史跃
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