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Wound protecting composition with bleeding-stopping and anti-bacterial functions and preparation method of wound protecting composition

A composition and wound technology, applied in the fields of medical science, bandages, absorbent pads, etc., can solve the problems of failure of anti-adhesion materials, non-healing wounds, slow wound healing, etc. Effect

Inactive Publication Date: 2015-03-04
WUXI ZHONGKE GUANGYUAN BIOMATERIALS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patented process allows create a special type of product that can stop bleeding quickly without causing any harm during surgery. It consists mainly three main parts - it includes various components like plastic films made from hydroxyethyl cellulose (HEC), EDTA, citric acid, glucosamine, etc., which are combined together by mixing them under specific conditions such as temperature, pressure, pH value, ion concentration, and chemical reaction parameters. These compositions have several beneficial properties including enhanced ability to prevent clotting when applied externally over large areas of skin surface caused by excessive swelling due to external factors like heat stress, inflammations, and tissue damage.

Problems solved by technology

This patents discusses various types of procedures performed after surgeries like those involving open abdomens where blood vessels cannot easily penetrate without causing damage due to lack of oxygen supply. Existing techniques involve cutting off these cuts before closing them, making cleanup steps unnecessary. Additionally, current dressings often require frequent changes overtime, leading to increased risk of complications. There has developed compositions made up entirely of biodegradables that provide quick heals when applied through stitching instead of sewing. These composites offer advantages compared to traditional gauzes, reducing patient discomfort and promotes faster recovery times.

Method used

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  • Wound protecting composition with bleeding-stopping and anti-bacterial functions and preparation method of wound protecting composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Embodiment 1: The preparation method of the wound protection composition with hemostatic and antibacterial function of the present embodiment comprises the following steps:

[0024] Dissolve one or two mixtures of polylactic acid-glycolic acid copolymer and polylactic acid in any organic solvent of DMF, acetone, THF, and hexafluoroisopropanol, and stir at 18°C ​​for 12 hours to prepare mass / volume concentration is 20% organic polymer mixed solution.

[0025] Add one or both of chitosan and chitin to acetic acid, ethanol and water to prepare a 0.5% hemostatic and antibacterial material solution, wherein the volume of acetic acid is 1% of the total solvent volume, and the volume of ethanol and water The ratio is 1:1.

[0026] Inject the organic polymer mixed solution into 5 syringes of the electrospinning equipment respectively, install a No. 5 stainless steel needle, inject the hemostatic and antibacterial material solution into the 3 syringes of the electrospinning eq...

Embodiment 2

[0028] Embodiment 2: The preparation method of the wound protection composition with hemostatic and antibacterial function of the present embodiment comprises the following steps:

[0029] Dissolve one or two mixtures of polylactic acid-glycolic acid copolymer and polylactic acid in any organic solvent such as DMF, acetone, THF, or hexafluoroisopropanol, and stir at 20°C for 12 hours to prepare mass / volume concentration is 30% organic polymer mixed solution.

[0030] Add one or both of chitosan and chitin to acetic acid, ethanol and water to prepare a 5% hemostatic and antibacterial material solution; wherein, the volume of acetic acid is 2% of the total solvent volume, and the volume of ethanol and water The ratio is 1:5.

[0031] Inject the organic polymer mixed solution into 6 syringes of the electrospinning equipment respectively, install a No. 5 stainless steel needle, inject the hemostatic and antibacterial material solution into 4 syringes of the electrospinning equip...

Embodiment 3

[0033] Embodiment 3: the preparation method of the wound protection composition with hemostatic and antibacterial function of the present embodiment, comprises the following steps:

[0034]Dissolve one or two mixtures of polylactic acid-glycolic acid copolymer and polylactic acid in any organic solvent such as DMF, acetone, THF, or hexafluoroisopropanol, and stir at 22°C for 12 hours to prepare mass / volume concentration is the organic polymer mixed solution of 50%.

[0035] One or both of chitosan and chitin are added to acetic acid, ethanol and water to prepare a 10% hemostatic and antibacterial material solution;

[0036] Wherein, the volume of acetic acid is 5% of the total solvent volume, and the volume ratio of ethanol to water is 1:10.

[0037] Inject the organic polymer mixed solution into 8 syringes of the electrospinning equipment respectively, install a No. 5 stainless steel needle, inject the hemostatic and antibacterial material solution into 4 syringes of the el...

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PUM

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Abstract

The invention discloses a wound protecting composition with bleeding-stopping and anti-bacterial functions and a preparation method of the wound protecting composition. The wound protecting composition comprises the following steps: (1) preparing an organic high molecular mixed solution; (2) adding one or two of chitosan and chitin into acetic acid, ethanol and water so as to prepare a bleeding-stopping and anti-bacterial material solution; (3) carrying out multi-spray-head electrostatic spinning so as to prepare a composite fiber material; and (4) drying the composite fiber material, removing residual solvents, and carrying out hot-press shaping, so as to prepare the wound protecting composition with the bleeding-stopping and anti-bacterial functions. The wound protecting composition disclosed by the invention has good bleeding-stopping and anti-bacterial effects, can be used for cleaning wounds and is good in biocompatibility; the water absorption rate is obviously increased, the bleeding-stopping time is greatly shortened, and the wounds are further protected.

Description

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Claims

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Application Information

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Owner WUXI ZHONGKE GUANGYUAN BIOMATERIALS
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