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Microdialysis analyzer and HPLC-MS combined equipment

A liquid-mass spectrometry and microdialyzer technology, used in instruments, scientific instruments, analytical materials, etc., can solve the problems of increasing labor, inability to perform, and affecting the speed of sample analysis, and achieve high sensitivity and high selectivity. Effect

Inactive Publication Date: 2015-02-25
CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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Problems solved by technology

However, the existing method of transferring samples manually increases the labor load and cannot be carried out when unattended, which affects the analysis speed of samples

Method used

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  • Microdialysis analyzer and HPLC-MS combined equipment
  • Microdialysis analyzer and HPLC-MS combined equipment
  • Microdialysis analyzer and HPLC-MS combined equipment

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Embodiment Construction

[0033] The following will clearly and completely describe the technical solutions in the embodiments of the present invention with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only some, not all, embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.

[0034] The application provides a combination device of a microdialyzer and a liquid chromatography-mass spectrometer. The control device controls the sampling switching device to realize the conduction between the quantitative loop and the microdialyzer or liquid phase spectrometer, so as to achieve sample collection or sample The purpose of entering the liquid mass spectrometer for separation and analysis, when the quantitative loop is connected to the microd...

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Abstract

The present invention provides microdialysis analyzer and HPLC-MS combined equipment. According to the microdialysis analyzer and HPLC-MS combined equipment, a control device is adopted to control a sampling switch device so as to achieve guide communication between the quantitative ring and the microdialysis analyzer or the HPLC-MS, such that the purpose that the sample is collected or the sample enters the HPLC-MS to separate and analyze is achieved; when the quantitative ring and the microdialysis analyzer form the guide communication through the sampling switch device, the sample collected from living organisms by the microdialysis analyzer enters the quantitative ring and is enriched, the control device controls the sampling switch device to achieve the guide communication between the quantitative ring and the HPLC-MS and the HPLC-MS is triggered to inject the sample after the first preset time, and the control device controls the sampling switch device again to achieve the guide communication between the quantitative ring and the microdialysis analyzer so as to enter the next time sample enrichment and analysis after the second preset time, such that the online combination of the microdialysis analyzer and the HPLC-MS, and the automated treatment on the dialyzate are achieved, the labor amount is reduced, and the analysis speed of the dialyzate is accelerated.

Description

technical field [0001] The invention mainly relates to the technical field of equipment combination, and more specifically relates to a combination equipment of a microdialyzer and a liquid spectrometer. Background technique [0002] At present, microdialysis technology and liquid chromatography-mass spectrometry (High Performance Liquid Chromatography-Mass Spectrometry, HPLC-MS, also known as liquid chromatography-mass spectrometry technology) have been widely used in the fields of experimental neurobiology and neurochemistry. Realized the extraction and analysis of samples from living biochemical samples. [0003] Among them, microdialysis (Microdialysis, MD) technology is a new technology that combines perfusion sampling and dialysis technology to realize biological sampling. It is based on the principle of dialysis. When the perfusion is performed under the dialysis tube, the substance will reversely diffuse along the concentration gradient. When the analyte diffuses th...

Claims

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Application Information

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IPC IPC(8): G01N30/24
Inventor 邢俊鹏宋凤瑞刘志强刘舒郑重皮子凤
Owner CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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