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Hydroxy-sphingomyelin 22:1 as biomarker for healthy ageing

A SM-OH22, healthy technology, applied in the field of improvement, can solve the problems that the comprehensive description of the molecular mechanism has not been reported, and the lack of long-lived metabolic phenotype research and other problems

Inactive Publication Date: 2015-01-28
NESTEC SA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Despite these findings, a comprehensive delineation of the molecular mechanisms influencing the aging process has yet to be reported
Furthermore, metabolic phenotype studies on longevity are still lacking

Method used

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  • Hydroxy-sphingomyelin 22:1 as biomarker for healthy ageing
  • Hydroxy-sphingomyelin 22:1 as biomarker for healthy ageing
  • Hydroxy-sphingomyelin 22:1 as biomarker for healthy ageing

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Embodiment

[0167] Subjects and Study Groups

[0168] Each individual and their family gave informed consent for the study to be conducted. In total, 541 subjects belonging to different age groups were enrolled for this study in northern Italy (including Bologna, Florence, Parma, Milan). The centenarian group consisted of 156 individuals (125 females and 31 males), the older group consisted of 363 individuals (205 females and 158 males), and the young adult group consisted of 22 individuals (10 women and 12 men).

[0169] The study protocol was approved by the ethics committee of the Sant'Orsola-Malpighi University Faculty of Medicine (Bologna, Italy). Resulting biological samples (serum and urine) were stored at -80°C until metabolomic analysis.

[0170] clinical chemistry

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Abstract

Using NMR / MS based metabonomics and targeted lipidomics approaches the inventors have explored the metabolic phenotypes of aging and longevity in a cohort compromising centenarians, elderly and young adults. The inventors have identified biomarkers for a reduced risk of developing ageing related chronic inflammatory disorders and propose a method of diagnosing a lifestyle that allows delaying and / or avoiding ageing related chronic inflammatory disorders using hydroxy-sphingomyelin SM-OH-22:1 as biomarker.

Description

technical field [0001] The present invention generally relates to healthy lifestyles and the prevention of aging-related chronic conditions. In particular, the invention relates to biomarkers and their use in detecting lifestyle improvements. Thus, the present invention provides, for example, hydroxy-sphingomyelin 22:1 (SM-OH 22:1) as a biomarker, and also provides a method for diagnosing a lifestyle using the biomarker hydroxy-sphingomyelin 22:1, wherein the life The approach allows delaying and / or avoiding chronic inflammatory conditions associated with aging. Background technique [0002] Aging is defined as a time-dependent decline in functional capacity and stress resistance, associated with increased risk of morbidity and mortality. Furthermore, the human aging phenotype is very heterogeneous and can be described as a complex mosaic resulting from the interaction of various environmental, stochastic and genetic-epigenetic variables. Decades of aging research have un...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/68G01N33/92
CPCG01N33/92G01N33/6893G01N33/50G01N33/6812G01N2405/08G01N2800/7042
Inventor S·科里诺I·蒙托柳鲁拉F-P·马丁P·A·盖S·A·D·莱兹
Owner NESTEC SA
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