A kind of thermosensitive copolymer and its synthetic method and hydrogel system

A copolymer and temperature-sensitive technology, which is applied in the field of hydrogel systems, temperature-sensitive copolymers and their synthesis, can solve the problems of poor reversibility of polypeptide temperature-sensitive hydrogels, and achieve fixed-point release, good biological Compatibility, application flexibility and convenient effect

Active Publication Date: 2016-08-24
UNIV OF ELECTRONICS SCI & TECH OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The purpose of the present invention is to overcome the problem of poor reversibility of the existing single amino acid component of the polypeptide temperature-sensitive hydrogel, and provide a novel temperature-sensitive copolymer composed of two amino acids, alanine and valine, and its hydrogel. Gel system, the hydrogen bond strength between the polypeptide chain segments in the copolymer can be tuned by composition, so as to obtain a temperature-sensitive hydrogel with good reversible properties

Method used

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  • A kind of thermosensitive copolymer and its synthetic method and hydrogel system
  • A kind of thermosensitive copolymer and its synthetic method and hydrogel system

Examples

Experimental program
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Effect test

Embodiment 1

[0034] A temperature-sensitive copolymer is a polyethylene glycol-poly(propylene glycol) composed of poly(alanine-valine) as a hydrophobic segment and monomethyl ether polyethylene glycol as a hydrophilic segment. amino acid-valine) block copolymer, wherein the content of alanine in the hydrophobic segment poly(alanine-valine) is 23.5wt%, and the content of valine is 76.5wt%.

[0035] Further, the content of monomethyl ether polyethylene glycol in the hydrophilic segment in the copolymer is 52.5 wt%, and the content of poly(alanine-valine) in the hydrophobic segment is 47.5 wt%.

[0036] The number average molecular weight of the monomethyl ether polyethylene glycol of the hydrophilic segment described in this example is 1000.

[0037] Further, the number average molecular weight of the monomethyl ether polyethylene glycol of the hydrophilic segment can also be 500, 2000, 3000, 4000 or 5000.

[0038] The synthetic method of the thermosensitive copolymer of the present embodim...

Embodiment 2

[0053] A temperature-sensitive copolymer is a polyethylene glycol-poly(propylene glycol) composed of poly(alanine-valine) as a hydrophobic segment and monomethyl ether polyethylene glycol as a hydrophilic segment. amino acid-valine) block copolymer, wherein the content of alanine in the hydrophobic segment poly(alanine-valine) is 15.2wt%, and the content of valine is 84.8wt%.

[0054] Further, the content of monomethyl ether polyethylene glycol in the hydrophilic segment in the copolymer is 45.0 wt%, and the content of poly(alanine-valine) in the hydrophobic segment is 55.0 wt%.

[0055] Further, the number average molecular weight of the monomethyl ether polyethylene glycol of the hydrophilic segment is 1500.

[0056] The synthesis method of the temperature-sensitive copolymer of this embodiment is the same as that of Embodiment 1.

[0057] The temperature-sensitive hydrogel system of this embodiment is prepared from a temperature-sensitive copolymer, and the concentration o...

Embodiment 3

[0059] A temperature-sensitive copolymer is a polyethylene glycol-poly(propylene glycol) composed of poly(alanine-valine) as a hydrophobic segment and monomethyl ether polyethylene glycol as a hydrophilic segment. Amino acid-valine) block copolymer, wherein, the content of alanine in the hydrophobic segment poly(alanine-valine) is 19wt%, and the content of valine is 81wt%.

[0060] Further, the content of monomethyl ether polyethylene glycol in the hydrophilic segment in the copolymer is 55.0 wt%, and the content of poly(alanine-valine) in the hydrophobic segment is 45.0 wt%.

[0061] Further, the number average molecular weight of the monomethyl ether polyethylene glycol of the hydrophilic segment is 5000.

[0062] The synthesis method of the temperature-sensitive copolymer of this embodiment is the same as that of Embodiment 1.

[0063] The temperature-sensitive hydrogel system of this embodiment is prepared from a temperature-sensitive copolymer, and the concentration of t...

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Abstract

The invention discloses a temperature-sensitive copolymer, a synthesis method thereof and a hydrogel system, which use poly(alanine-valine) as a hydrophobic segment and monomethyl ether polyethylene glycol as a hydrophilic Polyethylene glycol-poly(alanine-valine) block copolymer composed of chain segments, the content of alanine in the hydrophobic segment poly(alanine-valine) is 15.2~23.5wt% , the content of valine is 76.5~84.8wt%, the content of monomethyl ether polyethylene glycol in the hydrophilic segment in the copolymer is 45.0~55.0wt%, the hydrophobic segment poly(alanine-valine) The content is 45.0~55.0wt%. The polypolypeptide-polyether hydrogel of the present invention has two amino acid components, which can weaken the hydrogen bond in the hydrogel, and can regulate the hydrogen of the β-fold chain by regulating the composition of alanine and valine in the polypolypeptide. The strength of the bond, so as to obtain a polypeptide hydrogel with good reversible thermal transition behavior.

Description

technical field [0001] The invention belongs to the technical field of stimuli-responsive materials, and in particular relates to a temperature-sensitive copolymer, a synthesis method thereof, and a hydrogel system. Background technique [0002] Stimuli-responsive polymers refer to a class of environmentally sensitive materials that can respond to conformational changes when external conditions such as temperature, pH, and light and electromagnetics change. As one of the temperature-sensitive polymers, the polymer aqueous solution undergoes a sol-gel transition as the temperature increases. In this way, drugs or cells can be incorporated when the viscosity of the polymer aqueous solution is low, and gels can be formed in situ at the targeted sites with temperature changes, which can then be used as drug delivery systems or cell growth substrates. [0003] In temperature-sensitive hydrogel materials containing peptide components, the secondary structure of amino acids and na...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08G69/40C08G69/08C08J3/075C08L77/00
Inventor 郝建原朱萌刘钰叶友全
Owner UNIV OF ELECTRONICS SCI & TECH OF CHINA
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