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New application of traditional Chinese medicine compound medicinal composition

A use and drug technology, applied in the field of traditional Chinese medicine compound pharmaceutical compositions, can solve the problems of inability to recognize and express trophoblast cells, and the fetal placenta does not have lethality, etc., achieves good clinical application prospects, improves maternal-fetal immune tolerance, and improves maternal-fetal immunity. effect of tolerance

Active Publication Date: 2017-11-07
CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] HLA-G, human leucocyte antigen-G (human leucocyte antigen-G), has a similar domain function to MHC-I, but it has a high degree of isotype characteristics in different species, so maternal NK cells cannot recognize and express this Antigen trophoblast, so it is not lethal to fetal placenta

Method used

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  • New application of traditional Chinese medicine compound medicinal composition
  • New application of traditional Chinese medicine compound medicinal composition
  • New application of traditional Chinese medicine compound medicinal composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] The preparation of embodiment 1 pharmaceutical composition of the present invention

[0024] Weigh raw materials: Rehmannia glutinosa 24g, dogwood 12g, yam 12g, medlar 12g, dodder 12g, antler glue 12g;

[0025] Preparation method: the above six flavors, except for the antler gum, the other five flavors such as Rehmannia glutinosa are crushed into fine powder, sieved and mixed. Take antler gum, mix it with the above fine powder, dry and seal it for storage, make powder powder, and take it with water; or add 10g of refined honey and an appropriate amount of water for every 100g of powder, make pills, dry, and get pills; or take powder , adding pharmaceutically acceptable excipients or auxiliary ingredients to prepare granules, tablets, capsules, and oral liquids.

Embodiment 2

[0026] The preparation of embodiment 2 pharmaceutical compositions of the present invention

[0027] Weigh raw materials: Rehmannia glutinosa 24g, dogwood 9g, yam 12g, medlar 9g, dodder 12g, antler gum 12g;

[0028] Prepared according to the method of Example 1.

Embodiment 3

[0029] The preparation of embodiment 3 pharmaceutical composition of the present invention

[0030] Weigh raw materials: Rehmannia glutinosa 18g, dogwood 9g, yam 8g, medlar 9g, dodder 8g, antler glue 8g; prepared according to the method in Example 1.

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Abstract

The invention discloses application of a composition to preparation of drugs for improving the maternal-fetal immunologic tolerance. The composition comprises the following raw materials in parts by weight: 18-30 parts of prepared rehmannia root, 9-12 parts of dogwood, 8-16 parts of yams, 9-12 parts of medlar, 8-16 parts of semen cuscutae and 8-16 parts of deerhorn glue. The kidney-tonifying composition can improve the maternal-fetal immunologic tolerance, is expectedly used for treating pathological pregnancy such as habitual abortion, pregnancy induced hypertension and IUGR (intrauterine growth retardation) caused by maternal-fetal immunologic imbalance, and has a good clinical application prospect.

Description

technical field [0001] The invention relates to a new application of a traditional Chinese medicine compound pharmaceutical composition, in particular, an application in preparing a medicine for improving maternal-fetal immune tolerance. Background technique [0002] Pregnancy is a complex physiological process. From the perspective of immunology, the fetus and its appendages with paternal antigens are similar to semi-allogeneic transplants, which will cause the immune system of the mother to recognize and respond to them; Immune tolerance, that is, maternal-fetal immune tolerance, so that the fetus will not be rejected. Maternal-fetal immune tolerance is very important for a successful pregnancy. Once the maternal-fetal immune system is out of balance, pathological pregnancies such as habitual abortion, pregnancy-induced hypertension, and IUGR will occur. [0003] Traditionally, it is generally believed that any cell membrane has MHC-I as its surface marker, and MHC-I ref...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8945A61P37/06A61P15/06A61K35/32
CPCA61K9/08A61K9/16A61K9/20A61K9/48A61K35/32A61K36/39A61K36/40A61K36/804A61K36/815A61K36/8945A61K2300/00
Inventor 陆华梁丽梅刘芊辰刘志斌
Owner CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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