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Pharmaceutical composition of azelastine hydrochloride

A technology of azelastine and composition, which is applied in the direction of drug combination, active ingredient of heterocyclic compound, antipyretic, etc.

Active Publication Date: 2014-12-03
GUIZHOU YUNFENG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It can be seen that there are many limitations of azelastine as nasal or ophthalmic administration, for example, they are usually only used clinically for the treatment of allergic seasonal rhinitis and allergic perennial rhinitis

Method used

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  • Pharmaceutical composition of azelastine hydrochloride

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0140] Embodiment 1: preparation pharmaceutical composition

[0141] formula:

[0142] Azelastine Hydrochloride

[0143] Preparation method: make azelastine or its medicinal salt and the transdermal absorption accelerator miscible with the polyhydric alcohol and PEG; then mix the obtained mixed solution with an appropriate amount of polyhydric alcohol fatty acid ester, and add polyhydric alcohol Fatty acid ester to the full amount, cooling, that is.

Embodiment 2

[0144] Embodiment 2: preparation pharmaceutical composition

[0145] formula:

[0146] Azelastine Hydrochloride

[0147] Preparation method: make azelastine or its medicinal salt and the transdermal absorption accelerator miscible with the polyhydric alcohol and PEG; then mix the obtained mixed solution with an appropriate amount of polyhydric alcohol fatty acid ester, and add polyhydric alcohol Fatty acid ester to the full amount, cooling, that is.

Embodiment 3

[0148] Embodiment 3: preparation pharmaceutical composition

[0149] formula:

[0150] Azelastine Hydrochloride

[0151] Glycerol Triacetate

[0152] Preparation method: make azelastine or its medicinal salt and the transdermal absorption accelerator miscible with the polyhydric alcohol and PEG; then mix the obtained mixed solution with an appropriate amount of polyhydric alcohol fatty acid ester, and add polyhydric alcohol Fatty acid ester to the full amount, cooling, that is.

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PUM

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Abstract

The invention relates to a pharmaceutical composition of azelastine hydrochloride, specifically relates to pharmaceutical compositions of azelastine, particularly relates to pharmaceutical compositions of azelastine hydrochloride and more particularly relates to a nonaqueous gelatinous pharmaceutical composition. In one embodiment, the pharmaceutical composition contains azelastine or pharmaceutical salt thereof, polyhydric alcohol, polyethylene glycol and polyhydric alcohol fatty acid ester. The invention further relates to a preparation method of the pharmaceutical composition and pharmaceutical use of the pharmaceutical composition, for example, the invention further relates to the use of the composition in the treatment, relief or prevention of symptoms related to allergic and non-allergic diseases and the use in the treatment of dermatitis, such as allergic and / or contact dermatitis.

Description

technical field [0001] The present invention relates to a pharmaceutical composition of azelastine, in particular to a pharmaceutical composition of azelastine hydrochloride, and more particularly to a non-aqueous gel-like pharmaceutical composition. The invention also relates to a process for the preparation of the pharmaceutical compositions and their pharmaceutical use, for example the invention also relates to the use of such compositions for the treatment, alleviation or prevention of symptoms associated with allergic and non-allergic diseases, and for example in the treatment of dermatitis For example use in allergic and / or contact dermatitis. The compositions of the present invention have unexpected pharmaceutical properties. Background technique [0002] Azelastine, its hydrochloride (azelastine hydrochloride) is commonly used clinically, molecular formula C22H24ClN3O.HCl, molecular weight: 418.36, CAS registration number: 79307-93-0, and its cultural name is: (±)-1...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/55A61P17/00A61P29/00A61P37/08
Inventor 高永良黄维崧
Owner GUIZHOU YUNFENG PHARMA
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