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Chitosan quaternary ammonium salt product and preparation method thereof

A technology of chitosan quaternary ammonium salt and trimethylamine hydrochloride is applied in the field of medical devices and can solve the problems of poor stability, low substitution degree of chitosan quaternary ammonium salt, weak antibacterial activity and the like

Active Publication Date: 2014-11-26
JILIN JUNTONGXING BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The degree of substitution of chitosan quaternary ammonium salt prepared by the prior art is too low or too high, the antibacterial activity is weak, and the stability is poor, which is unsatisfactory

Method used

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  • Chitosan quaternary ammonium salt product and preparation method thereof
  • Chitosan quaternary ammonium salt product and preparation method thereof
  • Chitosan quaternary ammonium salt product and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Take 100g of epichlorohydrin and 130g of trimethylamine hydrochloride, put them in a reaction kettle, add 400g of 30% sodium hydroxide solution, stir for 2 hours, and make 2,3-epoxypropyltrimethylammonium chloride solution; Take 80g of chitosan, put it in an ultrasonic reactor, add 400g of isopropanol, 300g of 30% sodium hydroxide solution, 50g of sodium chloride, 10g of aluminum chloride, stir for 1 hour, add 2,3-epoxypropyltri Methylammonium chloride solution, select ultrasonic frequency 37kHz, heat up to 78°C, react for 3 hours, add 10% hydrochloric acid to adjust the pH value to 7.0, filter with suction, add 1000g of absolute ethanol to the filter cake, stir for 2 hours, filter with suction, filter Put the cake in an ultrasonic reaction kettle, add 1200 g of water, 150 g of sodium trethalate, select an ultrasonic frequency of 40 kHz, react for 2 hours, and spray dry to obtain chitosan quaternary ammonium salt microspheres.

specific Embodiment 2

[0028] Take 100g of epichlorohydrin and 130g of trimethylamine hydrochloride, put them in a reaction kettle, add 400g of 30% sodium hydroxide solution, stir for 2 hours, and make 2,3-epoxypropyltrimethylammonium chloride solution; Take 80g of chitosan, put it in an ultrasonic reactor, add 400g of isopropanol, 300g of 30% sodium hydroxide solution, 50g of sodium chloride, 10g of aluminum chloride, stir for 1 hour, add 2,3-epoxypropyltri Methylammonium chloride solution, select ultrasonic frequency 37kHz, heat up to 78°C, react for 3 hours, add 10% hydrochloric acid to adjust the pH value to 7.0, filter with suction, add 1000g of absolute ethanol to the filter cake, stir for 2 hours, filter with suction, filter Put the cake in an ultrasonic reaction kettle, add 1200g of water, 150g of sodium trethalate, select the ultrasonic frequency of 40kHz, react for 2 hours, add 1000kg of pure water, stir for 1 hour, pour it into a nasal sprayer, and make chitosan quaternary ammonium salt N...

Embodiment 3

[0030] Take 100g of epichlorohydrin and 130g of trimethylamine hydrochloride, put them in a reaction kettle, add 400g of 30% sodium hydroxide solution, stir for 2 hours, and make 2,3-epoxypropyltrimethylammonium chloride solution; Take 80g of chitosan, put it in an ultrasonic reactor, add 400g of isopropanol, 300g of 30% sodium hydroxide solution, 50g of sodium chloride, 10g of aluminum chloride, stir for 1 hour, add 2,3-epoxypropyltri Methylammonium chloride solution, select ultrasonic frequency 37kHz, heat up to 78°C, react for 3 hours, add 10% hydrochloric acid to adjust the pH value to 7.0, filter with suction, add 1000g of absolute ethanol to the filter cake, stir for 2 hours, filter with suction, filter Put the cake in an ultrasonic reactor, add 1200g of water, 150g of sodium trehalate, select the ultrasonic frequency of 40kHz, react for 2 hours, add 1000kg of pure water, stir for 1 hour, pour it into a rotary arm sprayer, and make chitosan quaternary ammonium salt Oral ...

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Abstract

The invention discloses a chitosan quaternary ammonium salt microsphere with antibacterial activity. The chitosan quaternary ammonium salt microsphere is characterized by being prepared from the following raw materials epichlorohydrin, trimethylamine hydrochlorate and chitosan, and generating the chitosan quaternary ammonium salt microsphere with 0.93 substitution degree under specific conditions according to specific ratio. The chitosan quaternary ammonium salt microsphere is enhanced in antibacterial activity, good in stability, excellent in effect, the treatment effect is apparently improved, and a good effect can be achieved.

Description

technical field [0001] The invention relates to a medical device prepared by using a medical dressing, in particular to a chitosan quaternary ammonium salt product and a preparation method thereof. Background technique [0002] Chitosan quaternary ammonium salt is an advanced chitosan derivative obtained by chemical modification of chitosan, and its full name is hydroxypropyltrimethylammonium chloride chitosan. Chitosan quaternary ammonium salt is non-toxic, biocompatible, biodegradable, and has antibacterial properties, and its antibacterial activity is related to the degree of substitution. The degree of substitution of chitosan quaternary ammonium salt prepared by the prior art is too low or too high, the antibacterial activity is weak, and the stability is poor, which is unsatisfactory. Contents of the invention [0003] The present invention provides a chitosan quaternary ammonium salt microsphere product with specific degree of substitution, strong antibacterial act...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/08A61K33/14A61K9/16A61K9/12A61K9/08A61K9/06A61P31/02A61P31/04
Inventor 孙法陈文建孙威李俊荣武兵
Owner JILIN JUNTONGXING BIOTECH
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