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Preparation method of 2-(4-benzyloxyphenyl) ethanol

A technology of benzyloxyphenyl and hydroxyphenylethanol, which is applied in the field of preparation of 2-ethanol, can solve the problems of low product yield, long reaction route, poor production efficiency, etc., and achieve high product yield and low product by-products Less, the effect of reducing production costs

Inactive Publication Date: 2014-10-08
NANTONG HUAFENG CHEM
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  • Claims
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Problems solved by technology

The existing 2-(4-benzyloxyphenyl)ethanol preparation process has a long reaction route, cumbersome methods, and many by-products, resulting in low product yield and poor production efficiency.

Method used

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  • Preparation method of 2-(4-benzyloxyphenyl) ethanol
  • Preparation method of 2-(4-benzyloxyphenyl) ethanol
  • Preparation method of 2-(4-benzyloxyphenyl) ethanol

Examples

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Embodiment

[0018] Add 200ml of water and 50g of p-hydroxyphenylethyl alcohol into a 1000ml three-necked bottle, stir and mix evenly, and add the pre-configured sodium hydroxide solution (16.5g of sodium hydroxide + 50ml of water) dropwise at room temperature for 2 hours; , under reduced pressure distillation at 0.085MPa vacuum, about 200ml of water is evaporated, stop steaming; add 250ml of toluene to reflux with water, heat up to reflux state, reflux with water until there is no water, keep reflux for 1.5h after bringing water; cool down, temperature When the temperature is lower than 30°C, start to add 50g of benzyl chloride dropwise, and the dropping time is controlled within 1h; after the dropwise addition, raise the temperature to reflux 100°C, and keep the temperature for 25h; Stir at ℃ for 0.5h, then stand still for 0.5h to separate layers, extract the organic layer and cool it down to below 20℃, stir slowly to crystallize for 8h to crystallize, filter to obtain a wet product, and ...

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Abstract

The invention discloses a preparation method of 2-(4-benzyloxyphenyl) ethanol. The preparation method comprises the following steps: stirring p-hydroxyphenylethyl alcohol and water, uniformly mixing, and dropwise adding a sodium hydroxide aqueous solution to perform salt forming reaction to generate 4-hydroxyphenylethyl alcohol sodium salt; then performing vacuum reduced pressure distillation, adding toluene to reflux with water, and then dropwise adding benzyl chloride to perform reaction to generate a 2-(4-benzyloxyphenyl) ethanol crude product; and then standing, filtering, crystallizing and drying to obtain a fine product namely 2-(4-benzyloxyphenyl) ethanol. The preparation method disclosed by the invention is simple and easy to operate, and is less in product by-product and high in product yield; preferably, the product yield can reach 85%; and the preparation method can be used for reducing the production cost and improving the production efficiency at the same time.

Description

technical field [0001] The invention relates to the field of biochemical industry, in particular to a preparation method of 2-(4-benzyloxyphenyl)ethanol. Background technique [0002] The molecular formula of 2-(4-benzyloxyphenyl)ethanol is C15H1602. It is an important organic chemical product, which is mainly used in high-end fine chemicals such as medicine, pesticide and new materials. The existing 2-(4-benzyloxyphenyl)ethanol preparation process has long reaction routes, cumbersome methods, and many by-products, which lead to problems such as low product yield and poor production efficiency. [0003] Therefore, in order to solve the above problems, a new technical solution is provided. Contents of the invention [0004] The purpose of this invention is to provide a kind of yield high, cost is low, the preparation method of simple 2-(4-benzyloxyphenyl) ethanol. [0005] The present invention is achieved through the following technical solutions: [0006] A kind of pre...

Claims

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Application Information

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IPC IPC(8): C07C41/16C07C43/23
CPCC07C41/16C07C37/66C07C43/23C07C39/235
Inventor 王德峰张耀兵王炳才张燕程
Owner NANTONG HUAFENG CHEM
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