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Anti-depression medicine composition and application thereof

A composition and anti-depressant technology, which is applied in the field of medicine, can solve the problem of no anti-depressant or anti-anxiety biological activity of gentianone, and achieve the effect of significant anti-depression, significant effect, and small toxic and side effects

Inactive Publication Date: 2014-10-08
王雪雁
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

By searching domestic and foreign literature, there is no literature report that norgentianone has antidepressant or anti-anxiety biological activity

Method used

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  • Anti-depression medicine composition and application thereof
  • Anti-depression medicine composition and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Example 1: Forced swimming test of nordaisyleaf gentianone on chronic unforeseen stimuli stress model

[0013] Male Kunming heavy mice, body weight 18-22 g, room temperature (20±2)°C, relative humidity (45%±5%), 4 mice per cage, free access to water and food, kept 12h / 12h day and night Regularity, 8:00am~8:00pm fluorescent lighting. Take 40 mice and divide them into groups completely randomly, with 8 mice in each group, which are divided into the following five groups: blank control group (distilled water), model control group (distilled water), positive control group (fluoxetine), nordaisy leaf gentianone (demethylbellidifolin, DB) high and low dose groups. The dose of fluoxetine was 10 mg / kg, and the high and low doses of DB were 320 and 160 mg / kg respectively. The blank control group and the model control group were given equal volumes of distilled water at the same time, and all animals were treated before 9:30 every morning. Oral administration. Each group began...

Embodiment 2

[0021] Example 2: Tail Suspension Test of Nordaisyleaf Gentione on Chronic Unforeseen Stimulus Stress Model

[0022] Male Kunming heavy mice, body weight 18-22 g, room temperature (20±2)°C, relative humidity (45%±5%), 4 mice per cage, free access to water and food, kept 12h / 12h day and night Regularity, 8:00am~8:00pm fluorescent lighting. Get 40 mice and divide them into groups completely randomly, 8 in each group, respectively as follows five groups: blank control group (distilled water), model control group (distilled water), positive control group (fluoxetine), DB high and low dose groups. The dose of fluoxetine was 10 mg / kg, and the high and low doses of DB were 320 and 160 mg / kg respectively. The blank control group and the model control group were given equal volumes of distilled water at the same time, and all animals were treated before 9:30 every morning. Oral administration. Each group began to administer the corresponding test substance 7 days before modeling, and...

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Abstract

The invention discloses an anti-depression medicine composition and an application thereof, belonging to the technical field of medicines. The medicine composition is prepared from an active component and auxiliary materials, wherein the active component comprises demethylation bellidifolin. As the demethylation bellidifolin has anti-depression biological activity, the medicine composition prepared from the demethylation bellidifolin can be used for treatment of depression.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to an antidepressant pharmaceutical composition and its application. Background technique [0002] With the progress of the times, the pace of urban life is accelerating, and social pressure is gradually increasing. Depression has become one of the most common mental illnesses. At present, depression has become a mental disease that seriously endangers the physical and mental health of human beings. According to the statistics of the World Health Organization, depression has become the fourth largest disease in the world, and it is estimated that by 2020, it may become the second largest disease after coronary heart disease. Therefore, it is very important to study effective antidepressant drugs. Most of the antidepressant drugs currently used in clinical practice are chemically synthesized drugs, but these drugs generally have relatively large side effects and depende...

Claims

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Application Information

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IPC IPC(8): A61K31/352A61P25/24
Inventor 刘学键
Owner 王雪雁
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