Liquid quality control substance with multiple autoantibodies and preparation method thereof

Abstract

The invention relates to the field of medical examination quality control, in particular to a liquid quality control material with multiple autoantibodies and a preparation method of the liquid quality control material. According to the liquid quality control material with the multiple autoantibodies, a quality control material matrix is serum or plasma and contains a composite protective agent and at least one autoantibody; the composite protective agent comprises ethylene glycol and glycerin, and the ratio of the ethylene glycol to the glycerin is 1:1; the composite protective agent accounts for 20-25% of the total volume of the quality control serum. The liquid quality control material with the multiple autoantibodies replaces current freeze-dried serum, it is detected that all analyzed components in the liquid quality control material are stable and can keep stable for one month at the room temperature, six months at the temperature of 4 DEG C and 15 months at the temperature of minus 20 DEG C. According to the preparation method, various kinds of potential pathogenic microorganisms are inactivated through a methylene-blue photosensitive inactivation method, no potential pathogenic microorganism harmfulness exists, and no species matrix error and no redissolution error exist.

Description

technical field [0001] The invention relates to the field of medical inspection quality control, in particular to a liquid quality control substance with multiple autoantibodies and a preparation method thereof. Background technique [0002] Quality control is an important topic in the inspection work. At present, the quality control serum used in domestic medical inspection is mostly freeze-dried serum. Freeze-dried serum has disadvantages such as species source error, reconstitution error during use, instability at room temperature or 4°C after reconstitution, few items, and inactivation of various potential pathogenic microorganisms. [0003] In order to solve the above problems, the applicant of this case invented a kind of multiple liquid quality control substances and its preparation method, and obtained the invention patent (CN101762710B). The variety of multiple liquid quality control substances is characterized in that: The matrix is ​​serum or plasma, which contai...

AI Technical Summary

Problems solved by technology

[0004] This multi-component liquid quality control has many components, which can not only meet the inspection requirements of conventional biochemistry and routine immunity, but also add a variety of antibodies according to the needs. However, the antibodies that can be added to this multi-liquid quality control are suitable for Infectious antibodies, and for autoantibodies, this liquid quality control material needs to be further improved