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Filtering particles from blood or other media

A medium and particle technology, applied in the field of methods, filter elements, and filter systems, can solve problems such as cell damage, and achieve the effect of simplifying the workflow and reducing stress

Inactive Publication Date: 2014-07-30
KONINKLJIJKE PHILIPS NV
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  • Abstract
  • Description
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Problems solved by technology

The disadvantage of this filter is that the retained cells are often damaged by the high pressure gradient

Method used

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  • Filtering particles from blood or other media
  • Filtering particles from blood or other media
  • Filtering particles from blood or other media

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Embodiment Construction

[0047] Rare cell isolation is increasingly important for eg circulating tumor cell (CTC) based cancer diagnostics. The challenge of this isolation is the need to detect these cells in very low concentrations as low as 1 cell per 7.5 ml in large numbers of blood cells (RBC and WBC).

[0048] Circulating tumor cells can differ from leukocytes in their size and firmness and the presence of epithelial cell surface markers (EPCAM). CTCs can be isolated based on specific immunocapture of EPCAM-positive cells using antibody-functionalized magnetic beads. CTCs that do not express this marker are therefore not captured.

[0049] Several authors have proposed size-selective cell isolation in axial filter systems, i.e. filters in which fluid flow is substantially perpendicular to the filter surface (see G. Vona et al. "Isolation by Size of Epithelial Tumor Cells", American Journal of Pathology, Vol. 156, pp. 57-63, January 2000). Due to the small pore size, the filter clogs easily. F...

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Abstract

A filter element (200) and a method are disclosed for retaining particles of a medium, for example (rare) cells of blood. The filter element (200) comprises at least one opening (220) that (i) has an elongate cross section and / or (ii) has a cross section that decreases in flow direction (x) and / or (iii) is bordered by a transparent wall. Preferably, the filter element (100, 200, 300) is provided with a plurality of elongate openings (220) of stepwise decreasing cross section that are arranged on a common transparent slide. Thus high flow rates can be realized throughout the filtering process, and the retained particles are immediately ready for visual inspection without a need for a further transfer.

Description

technical field [0001] The present invention relates to methods, filter elements, and filter systems for retaining particles of media, in particular for retaining cells from biological fluids such as blood or other bodily fluids. Background technique [0002] Rare cell isolation is an important example of an application in which particles (rare cells) are filtered from a medium (blood). In conventional filters used for this purpose, a plurality of pores are arranged in layers extending perpendicularly to the flow direction of the filtered medium. A disadvantage of such filters is that the retained cells are often damaged by high pressure gradients. Furthermore, if the cells should be further analyzed, the cells need to be transferred, which means additional stress on the cells. Contents of the invention [0003] It is an object of the present invention to provide means which allow improved filtration of particles from media, in particular filtration of (rare) cells from ...

Claims

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Application Information

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IPC IPC(8): G01N15/14B01L3/00
Inventor R·温贝格尔－弗里德尔A·范德斯托尔佩F·范赫默特
Owner KONINKLJIJKE PHILIPS NV
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