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Medicine composition for treating rhinitis

A composition and drug technology, which can be used in drug combinations, pharmaceutical formulations, and resistance to vector-borne diseases, etc. Bacterial action, prevention and treatment of rhinitis

Inactive Publication Date: 2014-07-02
陈光健
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there are no reports on the application of small molecule active peptides in rhinitis

Method used

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  • Medicine composition for treating rhinitis
  • Medicine composition for treating rhinitis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Add 0.45% chlorhexidine gluconate, 15% glycerin and 1.0% hydrogenated castor oil to 3.0% small molecule active peptide, stir and heat to dissolve, after mixing evenly, add 800ml of purified water after stopping heating, wait until When the temperature drops to 25°C, add 0.01% mint essence and 0.05% fragrant rice essence, stir and mix well, pass through a 0.45μm microporous filter membrane, add purified water to the filtrate to make up to 1000ml, and then fill it, 15ml per bottle, After electromagnetic induction sealing, it is sterilized by moist heat at 95°C for 30 minutes.

[0030] The preparation method of above-mentioned small molecule active peptide is:

[0031] Weigh 1000 g of the dried worm body of Periplaneta americana, add 90% ethanol to reflux and extract 3 times, add 8 times, 6 times and 6 times respectively each time, filter, and recover ethanol from the filtrate under reduced pressure. Recover until there is no ethanol smell, refrigerate the concentrated so...

Embodiment 2

[0033] Add 0.3% chlorhexidine gluconate, 15% glycerin and 0.6% hydrogenated castor oil to 3.0% small molecular active peptide, stir and heat to dissolve, after mixing evenly, stop heating and add 1000ml purified water, wait until the temperature When the temperature drops to 40°C, add 0.01% mint essence and 0.03% fragrant rice essence, stir and mix well, pass through a 0.45μm microporous filter membrane, add purified water to the filtrate to make up to 2000ml, then fill it, 15ml per bottle, electric After magnetic induction sealing, sterilize with damp heat at 95°C for 30 minutes.

[0034] The preparation method of above-mentioned small molecule active peptide is:

[0035] Weigh 2000 g of Periplaneta americana, add 80% ethanol to reflux and extract 3 times, add 8 times, 6 times and 6 times respectively each time, filter, and recover ethanol from the filtrate under reduced pressure. Recover until there is no ethanol smell, refrigerate the concentrated solution at around 7°C fo...

Embodiment 3

[0037] Add 0.5% chlorhexidine gluconate, 18% glycerin and 1.0% hydrogenated castor oil to 5.0% small molecule active peptide, stir and heat to dissolve, after mixing evenly, stop heating and add 3000ml purified water, wait until temperature When the temperature drops to 20°C, add 0.013% mint essence and 0.05% fragrant rice essence, stir and mix well, pass through a 0.45μm microporous membrane, add purified water to the filtrate to 4000ml, and fill it, 15ml per bottle, electromagnetic induction After sealing, it is sterilized by moist heat at 95°C for 30 minutes.

[0038] The preparation method of above-mentioned small molecule active peptide is:

[0039] Weigh 1000 g of Periplaneta americana, add 70% ethanol to reflux and extract 3 times, add 8 times, 6 times and 6 times respectively each time, filter, and recover ethanol from the filtrate under reduced pressure. Recover until there is no ethanol smell, refrigerate the concentrated solution at about 2°C for 72 hours, absorb t...

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PUM

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Abstract

The invention discloses a medicine composition for treating rhinitis. The medicine composition for treating rhinitis comprises the following constituents: micromolecular active peptide, chlorhexidine gluconate, glycerol, hydrogenated castor oil, mint essence and fragrant rice essence. The medicine composition disclosed by the invention is used as a spray, high in bacteriostatic action, capable of inhibiting bacteria such as staphylococcus aureus, candida albicans and escherichia coli, suitable for cleanliness and disinfection for nasal cavity, remarkable in effects on people with nasal obstruction, turbid nasal discharge, sneezing, headache, hyposmia, mycteroxerosis and the like due to acute and chronic rhinitis, allergic rhinitis, nasosinusitis, cold and the like.

Description

technical field [0001] The invention relates to a pharmaceutical composition, in particular to a pharmaceutical composition for treating rhinitis. Background technique [0002] Rhinitis is an inflammation of the nasal mucosa caused by bacteria, viruses, allergens, various physical and chemical factors, and certain systemic diseases. increase. Today, as the air quality is getting worse and worse, the incidence of rhinitis is also increasing. Various viruses and bacteria are breathed into our nasal cavity along with the dust in the air, and adhere to the nasal mucosa, causing symptoms such as inflammation and edema of the nasal mucosa. Therefore, it is necessary to find a formula that can clean the nasal cavity, prevent and treat rhinitis Drugs are the most urgent problem at present. [0003] Studies have found that small molecular active peptides composed of 2-4 amino acids can not only directly enter cells through the cell membrane to improve cell repair, but also produce...

Claims

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Application Information

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IPC IPC(8): A61K38/05A61K38/06A61K38/07A61P11/02A61P11/00A61K31/191
CPCY02A50/30
Inventor 陈光健
Owner 陈光健
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