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Ivermectin in-body gel injection and preparation method thereof

A body gel injection, ivermectin technology, applied in the direction of pharmaceutical formula, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problems that cannot meet the needs, have no long-term effect, etc. , to achieve the effects of reducing the chance of secondary infection, definite clinical effect, and simple and easy-to-operate preparation method

Active Publication Date: 2015-12-30
HENAN HEIMA ANIMAL PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these patented preparations do not have long-acting effects and cannot meet the current veterinary clinical needs for long-acting ivermectin preparations

Method used

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  • Ivermectin in-body gel injection and preparation method thereof

Examples

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Comparison scheme
Effect test

preparation example Construction

[0066] The preparation method of described injection is as follows:

[0067] Step 1), take 20% organic solvent, add ivermectin and stir to dissolve it, as No. I solvent

[0068] liquid spare,

[0069] Step 2), take another remaining amount of organic solvent, add the prescribed amount of PLGA, stir to dissolve, and then

[0070] Add the prescribed amount of carbomer-941, stir and dissolve as II solution for later use,

[0071] Step 3), mix I solution and II solution, add the prescribed amount of Tween-80 and stir evenly,

[0072] Step 4), filter with a 0.22um filter terminal, potting, and sterilize at 100°C for 30 minutes.

[0073] The organic solvents are respectively one of N-methylpyrrolidone and N,N-dimethylformamide.

[0074] The operations are all carried out at room temperature, and water pollution is avoided during the entire preparation process of the preparation.

Embodiment 1

[0075] Embodiment 1: a kind of ivermectin in vivo gel injection its raw and auxiliary material components are as follows:

[0076] Active ingredient: Ivermectin 5g

[0077] Excipient: PLGA10g

[0078] Carbomer - 9411g

[0079] Tween-800.1g

[0080] N-Methylpyrrolidone 90ml

[0081] The preparation steps of this injection are as follows: the ivermectin of prescription quantity is added 20mlN-methylpyrrolidone

[0082] in, stir to dissolve. --I solution

[0083] Take the remaining amount of N-methylpyrrolidone, add PLGA and Carbomer-941 respectively, and stir to dissolve. --II solution (spare)

[0084] Mix liquid III and liquid II, add the prescribed amount of Tween-80, and stir well.

[0085] 0.22um filter terminal filter, the measured pH is 8.5. Potting. Sterilize at 100°C for 30 minutes.

Embodiment 2

[0086] Embodiment 2: a kind of ivermectin in vivo gel injection its raw and auxiliary material components are as follows:

[0087] Active ingredient: Ivermectin 5g

[0088] Excipient: PLGA10g

[0089] Carbomer - 9411g

[0090] Tween-800.2g

[0091] N-Methylpyrrolidone 85ml

[0092] The preparation method is the same as in Example 1.

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Abstract

The invention relates to an invermectin in-vivo gel injection and a preparation method thereof, aiming at providing a long-acting injection for preventing and treating livestock parasite infections, and a preparation method thereof. Raw materials required by every 100 mL of the invermectin in-vivo gel injection comprise 5 g-10 g of injection grade invermectin, 10 g-20 g of poly(lactic-co-glycolicacid) (PLGA), 1 g -2 g of carbomer-941, 0.1 g -0.2 g of tween-80 and 85 mL-90 mL of an organic solvent. The injection is an in-vivo gel prepared from invermectin, and is used for preventing and treating gastrointestinal parasites of cattle, pigs and sheep, lungworm and externally parasitic diseases such as lice, and mites and fly larvae. The injection has an obvious effect; and the preparation method of the injection is simple and easily operational, and is suitable for large-scale production.

Description

technical field [0001] The invention belongs to the technical field of veterinary antiparasitic drugs, specifically relates to an ivermectin in vivo gel injection and a preparation method thereof, and aims to provide a long-acting injection for preventing and treating parasitic infections in livestock and its preparation method. Preparation. Background technique [0002] Ivermectin is made from Avi Semi-synthetic macrolide multicomponent produced by fermentation of Streptomyces avermitilis antibiotic , is a new type of broad-spectrum, high-efficiency, low-toxicity antibiotics parasite medicine, against internal and external parasites, especially Nematodes And arthropods have a good repellent effect. Ivermectin is widely used for gastrointestinal nematodes, lung nematodes and parasitic arthropods of cattle, sheep, horses and pigs, intestinal nematodes of dogs, ear mites , scabies mite , heartworms and microfilariae, and poultry gastrointestinal nematodes and Exte...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/08A61K31/7048A61K47/34A61P33/02A61P33/10A61P33/14
Inventor 罗振军吴小萍保广春吴营王天柱
Owner HENAN HEIMA ANIMAL PHARM CO LTD
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