Application of unilaterally-substituted phenyl urea compound

Abstract

The invention discloses a unilaterally-substituted phenyl urea compound (as shown in formula I) and an application thereof. The structural formula of the compound is as shown in the formula I in description, wherein R1, R2 and R3 in the formula I represent hydrogen, C1-C4 alkyl, C1-C4 halo-alkyl, C1-C4 alkoxy, C1-C4 alkyl sulfenyl, halogen, nitryl, cyan and hydroxyl. The compound VS01 disclosed by the invention has an obvious ecdysone antagonistic activity on 20E and also has a certain killing activity on lepidopteron; the compound is simple in structure and large in modification space, and can be used for in-depth study as an ecdysone antagonist type lead compound with a totally new structure.

Description

technical field [0001] The invention relates to the application of a unilaterally substituted phenylurea compound in preventing and controlling agricultural pests. Background technique [0002] The mechanism of action of insect growth regulators (IGRs) is different from that of traditional insecticides. They have the advantages of high selectivity, safety to natural enemies and non-target organisms, and good environmental compatibility. They meet the needs of sustainable agricultural development and have broad application prospects. . At present, three types of IGRs have been successfully developed, including ecdysone analogs represented by dihydrazides, juvenile hormone analogs, and chitin synthesis inhibitors represented by benzoylureas. [0003] In the growth process of insects, ecdysone plays a very important regulatory role. It is a class of sterol compounds secreted by the insect prothymus, which can cause larvae to molt and promote metamorphosis. Due to the complex ...

AI Technical Summary

Problems solved by technology

With the continuous expansion of the use time and scope of such agents, the shortcomings of low contact activity, slow action, and drug resistance have become increasingly prominent.

In order to overcome the defects of existing dihydrazide compounds, many units at home and abroad (such as Nankai University, Jiangsu Pesticide Research Institute, East China University of Science and Technology, China Agricultural University, Kyoto University, Japan, etc.) are actively carrying out research on dihydrazide compounds, mainly The chemical modification of substituents with the dihydrazide structure as the parent skeleton can make up for the deficiency of the dihydrazide compounds to a certain extent, but because the modified skeleton is single, it cannot break through the limitation of the dihydrazide skeleton, so it cannot be completely changed. Defects of bishydrazide compounds

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