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Qiangli Naoxinkang tablet and its preparation method

A powerful technology for Naoxinkang tablets, which is applied in the field of preparation of pure biological pharmaceutical preparations, can solve problems such as quality differences and affect the overall efficacy of drugs, and achieve the effects of improving quality, shortening labor hours, and reducing costs

Active Publication Date: 2016-03-23
TONGHUA JITONG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0022] Armillaria armillaria extract is usually a purchased product with no quality index restrictions. Different batches and different manufacturers have different quality, which affects the overall efficacy of the drug.

Method used

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  • Qiangli Naoxinkang tablet and its preparation method
  • Qiangli Naoxinkang tablet and its preparation method
  • Qiangli Naoxinkang tablet and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0039] Screening of Armillaria slant culture medium.

[0040] Through the test and comparison of the growth and speed of Armillaria armillaria hyphae on four kinds of original medium. Wheat bran powder and cocoon pupa powder medium are most suitable for making armillaria culture medium, the medium is: wheat bran powder 0.5%; glucose 3%, potassium dihydrogen phosphate 0.75%, cocoon pupa powder 0.5%, agar 1.0% , magnesium sulfate 0.3%, VB 1 0.005%, water 93.945%.

[0041] The influence of table 1-1 different culture media on Armillaria mycelia growth ( ±S.Dn﹦3)

[0042]

[0043] The change of the composition of the culture medium: wheat bran powder and cocoon pupae powder are selected, which can improve the growth rate of Armillaria armillaria mycelia and the growth of Armillaria armillaria mycelium is more robust, which is conducive to the preparation of Armillaria armillaria.

experiment example 2

[0045] Screening of temperature for Armillaria armillae fermentation culture.

[0046] The temperature range from 15-30°C has been tested and compared for many times, and 26-28°C is more suitable for the growth of Armillaria armillaria, which can activate the growth rate of Armillaria armillaria mycelia, and obtain more robust and vigorous excellent Armillaria armillaria, thus Improve the quality of Armillaria mellea, and improve the efficacy of Qiangli Naoxinkang Tablets. Therefore, by changing the cultivation temperature, the working hours can be shortened and the efficacy of Qiangli Naoxinkang Tablets can be improved, which has achieved twice the result with half the effort.

[0047] Table 2-1 Effect of different temperatures on Armillaria mycelium growth (colony diameter mm)

[0048]

[0049] It can be seen from Table 2-1 that the effects of different temperatures on the growth of Armillaria armillaria mycelium are significantly different. When the culture temperature i...

Embodiment 3

[0054] A Qiangli Naoxinkang tablet, which is made of the following raw materials: 1500g of Salvia miltiorrhiza, 1500g of Armillaria armillaria extract, and 125g of royal jelly;

[0055] The preparation method of described Armillaria armillaria extract is:

[0056] (1) Bacteria culture on inclined plane

[0057] Slant culture medium: 0.5% wheat bran powder; 3% glucose, 0.75% potassium dihydrogen phosphate, 0.5% cocoon powder, 1.0% agar, 0.3% magnesium sulfate, VB 1 0.005%, water 93.945%; under sterile conditions, inoculate the preserved strains on the prepared slant medium by digging blocks, the inoculation amount is 1:10, and the temperature is controlled at 28°C; cultivate for 10-15 days, and wait for the slant The mycelia changed from white to brown, and were transferred to the primary and secondary shake flasks for culture.

[0058] (2) Primary and secondary shake flask strain culture

[0059] Primary and secondary shake flask culture medium: 2% glucose, 0.75% potassium ...

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Abstract

The present invention involves a pure Chinese medicine strong brain -hearted film and preparation method.The strong brain -hearted tablet is made of the following raw medicines: 1500g of Salva, 1500g of Honey Ellabal extract, and 125g of royal jelly.The preparation method of the honey cytosococcus extract is: (1) Cultivation of diagonal bacteria.(2) Cultivation of first and second -level bottle bacteria.(3) Cultivation of first and second -level seed cans.(4) Cultivation of fermentation tanks.Mergersal inspection: 1. Cultivation of bacteria accounted for more than 80%.2. PH: 5.0-5.2.2.26-28 ° C is more suitable for the growth of honey ring bacteria, which can activate the growth rate of honey ring fungus, and obtain a stronger and more vibrant excellent honey ring bacteria, thereby increasing honeyThe quality of cyclic bacteria can shorten the work hours and better improve the efficacy of strong brain -hearted tablets.The time for the fermentation of the honey ring bacteria to extract liquid is short, shortening the labor time and reducing costs.

Description

[0001] technical field [0002] The invention relates to a preparation method of a pure biological drug preparation, namely Qiangli Naoxinkang Tablet and the preparation method. Background technique [0003] Qiangli Naoxinkang Tablet is the national exclusive variety approved by the State Food and Drug Administration as owned by Tonghua Jitong Pharmaceutical Co., Ltd. It was approved for production by the State Food and Drug Administration in 2008, and the drug approval number is Guoyao Zhunzi Z20080087; drug re-registration The batch number is: 2013R00012. Prescription of Qiangli Naoxinkang Tablets: Salvia miltiorrhiza 1500g, armillaria extract 1500g, royal jelly 125g. Preparation method: Salvia miltiorrhiza, extract of Armillaria miltiorrhiza, and three herbs above royal jelly, take 75g of salvia miltiorrhiza, crush it into fine powder; soak the remaining salvia miltiorrhiza in water and decoct three times, the first and second times are 2 hours each, and the third time is ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/537A61K9/20A61P37/04A61P9/10A61P29/00A61P31/04C12N1/14C12R1/645
Inventor 杨静李春娥罗晓萍
Owner TONGHUA JITONG PHARMA
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