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Medicine for preventing and treating exaggerated pain after anesthesia

A drug and exaggerated technology, which is applied in the field of drugs to prevent and treat exaggerated pain after anesthesia, to achieve the effect of reducing the expression of NMDA receptors

Inactive Publication Date: 2014-04-23
威海市妇女儿童医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Animal experiments have shown that formalin-induced hyperalgesia can be suppressed by taking Celebrex beforehand, but the subsequent administration is ineffective, but subarachnoid injection of non-selective COX inhibitors can inhibit hyperalgesia before and after the onset of hyperalgesia

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Example 1, the weight ratio of raw materials: 20 parts of fig leaves, 10 parts of sarcophagus, 6 parts of dendrobium, 10 parts of kudzu rice, 6 parts of coriander, 10 parts of Peucedanum, 10 parts of almonds, 10 parts of eucalyptus 10 parts of ebony plum, 2 parts of Qingzizi, 6 parts of papaya, and 20 parts of white horse bone.

[0029] The preparation method of embodiment 1 is: mix ficus leaf, sarcocarpus, dendrobium, kudzu rice, coriander, peucedanum, almond, eucalyptus, ebony, green scorpion, papaya, white horse bone, add water and decoct, Take the filtrate after 30 minutes, add water to the dregs of the medicine and continue to decoct for 20 minutes, then take the filtrate, combine the two filtrates, divide into two parts and take it in the morning and evening.

Embodiment 2

[0030] Example 2, raw material drug weight ratio: 10 parts of ficus leaves, 6 parts of sarcocarpus, 3 parts of dendrobium, 6 parts of kudzu rice, 3 parts of coriander, 6 parts of Peucedanum, 6 parts of almonds, 6 parts of eucalyptus 6 parts of ebony plum, 1 part of green scorpion, 3 parts of papaya, and 10 parts of white horse bone.

Embodiment 3

[0031] Example 3, the weight ratio of raw materials: 20 parts of ficus leaves, 10 parts of sarcophagus, 6 parts of dendrobium, 10 parts of kudzu rice, 6 parts of coriander, 10 parts of Peucedanum, 10 parts of almonds, 10 parts of eucalyptus 10 parts of ebony plum, 2 parts of Qingzizi, 6 parts of papaya, and 20 parts of white horse bone.

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PUM

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Abstract

The invention discloses a medicine for preventing and treating exaggerated pain after anesthesia and aims to solve the problem of treatment of high sensitivity of pain after anesthesia. The medicine is characterized by being prepared from the following raw materials according to weight ratio: red fruit fig-tree leaves, herba sarcandrae, dendrobe, nostoc sphaeroides, centipeda minima, common hogfenneI roots, almonds, folium eucalypti, smoked plum, seeds of feather cockscomb, pawpaw and serissa serissoides. Clinical experiment results show that the medicine has the characteristics of good curative effect and high safety in relieving post-operation pain, and is worthy of clinical application and promotion.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicines, in particular to a medicine for preventing and treating exaggerated pain after anesthesia. Background technique [0002] Previous animal experiments and human studies have shown that anesthesia is closely related to postoperative pain hypersensitivity, such as isoflurane 0.2%-0.3% MAC, remifentanil anesthesia, pain hypersensitivity may occur after taking naloxone antagonistic opioids, Also known as exaggerated pain. Postoperative pain hypersensitivity was associated with high expression of NMDA receptors, nitric oxide and nitric oxide synthase, and central sensitization. Animal experiments have shown that formalin-induced hyperalgesia can be suppressed by pre-administration of Celebrex, but post-medication is ineffective, but subarachnoid injection of non-selective COX inhibitors can inhibit hyperalgesia before and after the onset of hyperalgesia. How to block the lowering of the pa...

Claims

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Application Information

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IPC IPC(8): A61K36/8984A61P25/04A61P29/00
Inventor 刘幸福钟学文
Owner 威海市妇女儿童医院
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