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Method for preparing individual porous thyroid cartilage support

A thyroid cartilage and software technology, which is applied in the field of preparation of personalized porous thyroid cartilage scaffolds, can solve the problem of inability to meet patients' personalized needs for the shape of the scaffold and other problems.

Active Publication Date: 2015-06-24
GUANGXI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0011] Based on the above situation, the present invention provides a preparation method for preparing a personalized porous thyroid cartilage scaffold with a simple process flow and no special rapid prototyping machine, so as to solve the problem that the thyroid cartilage scaffold produced by the current existing preparation method cannot meet the needs of patients. Individual requirements for the shape of the stent, and requirements for the interconnected pores inside the stent, etc.

Method used

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  • Method for preparing individual porous thyroid cartilage support
  • Method for preparing individual porous thyroid cartilage support
  • Method for preparing individual porous thyroid cartilage support

Examples

Experimental program
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Effect test

Embodiment 1

[0046] A method for preparing a personalized porous thyroid cartilage scaffold, the preparation steps are as follows:

[0047] Step 1: Use high-precision medical CT to collect data from the living body, and use a segmentation algorithm to segment the thyroid cartilage area, and export the data in text format; the specific method is:

[0048] (i) Use Philips / iCT256 equipment to continuously scan the living body, the scanning voltage is 120KV, the scanning layer thickness is 0.625mm, the resolution is 1024*1024, and the side length of the field of view window is 140mm. These image data are imported into the MIMICS software and stacked sequentially along the direction of the helical scanning axis. The horizontal and vertical axes of the rectangular CT image are used as the X and Y axes, and the vertical XY plane is used as the Z axis to establish a space Cartesian coordinate system;

[0049] (ii) Use the threshold segmentation algorithm, the threshold is set to 81Hu, and cooperat...

Embodiment 2

[0065] A method for preparing a personalized porous thyroid cartilage scaffold, the preparation steps are as follows:

[0066] Step 1: Use high-precision medical CT to collect data from the living body, and use a segmentation algorithm to segment the thyroid cartilage area, and export the data in text format; the specific method is:

[0067] (i) Use Philips / iCT256 equipment to continuously scan the living body, the scanning voltage is 125KV, the scanning layer thickness is 0.675mm, the resolution is 1024*1024, and the side length of the field of view window is 170mm. These image data are imported into the MIMICS software and stacked sequentially along the direction of the helical scanning axis. The horizontal and vertical axes of the rectangular CT image are used as the X and Y axes, and the vertical XY plane is used as the Z axis to establish a space Cartesian coordinate system;

[0068] (ii) Use the threshold segmentation algorithm, the threshold is set to 78Hu, and cooperat...

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Abstract

The invention discloses a method for preparing an individual porous thyroid cartilage support. The method comprises the following steps: performing data acquisition on a living body by using high-precision medical CT, partitioning a thyroid cartilage area by using a partitioning algorithm, and exporting the data in a text format; performing in-vitro isolated point removal, noise reduction, surface smoothing and reverse three-dimensional modeling on the acquired data in reverse engineering software; performing rapid mold design by using industrial CAD (Computer-Aided Design) software UG-NX, and preparing a rapid mold through rapid molding; preparing foam slurry which takes hydroxylapatite particles as a filling matrix by using a gel foaming method, injecting the slurry into the rapid mold, and initiating an in-situ curing reaction so as to finish preparation of a cartilage support blank; demolding and drying the support blank, and performing high-temperature sintering, thereby obtaining the individual porous thyroid cartilage support. After the support is implanted into the body of a patient, the surrounding cartilage metrocyte and growth factors can be effectively absorbed, a metabolism channel is provided for growth of the cartilage metrocyte, and the cartilage metrocyte grows into individual bones.

Description

technical field [0001] The invention belongs to the field of individualized and digitalized design and manufacture of medical implants, in particular to a method for preparing a personalized porous thyroid cartilage support for repairing laryngeal thyroid cartilage defects. Background technique [0002] Laryngeal trauma and tumor surgery often cause large-scale defects of the laryngeal cavity and trachea, and the supporting function of the laryngotracheal cartilage is lost, so extubation is often not possible after surgery. It is of great clinical significance to reconstruct and repair laryngeal cartilage defects, restore its supporting function, and preserve breathing, swallowing and pronunciation functions to the greatest extent. [0003] Bone scaffolds prepared from the bioceramic material hydroxyapatite (HA) have been widely used as bone substitutes in clinical practice due to their inorganic composition similar to natural bone composition and high biocompatibility. Com...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/56A61L27/42G06F17/50
Inventor 夏薇曹高翔张龙城蒋利浩王灿曾建民
Owner GUANGXI UNIV
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