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Red ginseng extract as well as preparation method and application thereof

A red ginseng extract and extract technology, which is applied in the direction of drug combination, medical formula, plant raw materials, etc., can solve the problem of lack of saponin components, etc., and achieve the effect of simple and clear chemical composition, easy quality control, and good pharmacological activity

Active Publication Date: 2014-03-12
SHAN DONG DONG E E JIAO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the current pharmacological research mainly focuses on monomer components such as polysaccharides and high-content saponins, and there is a lack of overall research on the saponin components in red ginseng; the separation of saponin components with pharmacological activity in red ginseng can not only save preparation The consumption of the monomer compound process is also in line with the onset mechanism of the multi-component synergistic effect of traditional Chinese medicine, which is beneficial to the research on the pharmacodynamic mechanism of red ginseng and the quality control of traditional Chinese medicine preparations

Method used

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  • Red ginseng extract as well as preparation method and application thereof
  • Red ginseng extract as well as preparation method and application thereof
  • Red ginseng extract as well as preparation method and application thereof

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Embodiment 1

[0029] The preparation method of embodiment 1 red ginseng extract

[0030] (1) Take medicinal red ginseng as raw material, add 10 times the amount of water to soak for 1 hour, heat and reflux for 2 hours for the first time, add 5 times the amount of water for 2 hours, and add 3 times the amount for the third time The water was heated to reflux for 1 hour, all the extracts were combined, filtered and concentrated.

[0031] (2) The extract was separated by reverse ODS-C18 medium-pressure column chromatography, 8 L was eluted with 30% methanol-water, and discarded; 10 L was eluted with 50% methanol-water, concentrated under reduced pressure, and freeze-dried to obtain components.

Embodiment 2

[0032] The preparation method of embodiment 2 red ginseng extract

[0033] (1) Take medicinal red ginseng as a raw material, add 10 times the amount of water to soak for 1 hour, heat and reflux for 2 hours for the first time, add 8 times the amount of water for 1.5 hours, and add 3 times the amount for the third time The water was heated to reflux for 0.5 hour, all the extracts were combined, filtered and concentrated.

[0034] (2) The liquid was separated by reverse ODS-C18 medium pressure column chromatography, 6 L was eluted with 40% methanol-water, and discarded; 5 L was eluted with 60% methanol-water, concentrated under reduced pressure, and freeze-dried to obtain components.

Embodiment 3

[0035] The preparation method of embodiment 3 red ginseng extract

[0036] (1) Take medicinal red ginseng as raw material, add 8 times the amount of water to soak for 1 hour, heat and reflux for 2 hours for the first time, add 8 times the amount of water for 2 hours and heat and reflux for 2 hours, and add 3 times the amount for the third time The water was heated to reflux for 1 hour, all the extracts were combined, filtered and concentrated.

[0037] (2) Take the liquid and separate it by reverse ODS-C18 medium pressure column chromatography, elute 8L with 40% methanol-water, discard; elute 4.5L with 70% methanol-water, concentrate under reduced pressure, freeze-dry, get the components.

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Abstract

The invention discloses a red ginseng extract. The extract is characterized by containing ginsenoside Rg1, ginsenoside Re, ginsenoside Rf, notoginsenoside R2 and ginsenoside Ro. A preparation method of the extract comprises the following steps: cutting red ginseng serving as a medicinal material into pieces, adding water in an amount which is 3-10 times that of the red ginseng, soaking for 0.5-2 hours, heating and performing reflux extraction for 1-2 hours, extracting for 1-3 times, combining extraction solutions, filtering and concentrating; separating and purifying a concentrated solution with a reverse phase silica gel column; eluting with 30-40 percent methanol-water by 4-10L, and discarding; and eluting with 50-70 percent methanol-water by 4-6L, collecting an eluent and concentrating to obtain active ingredients.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine chemistry, and in particular relates to an effective component extracted from red ginseng, a preparation method thereof, and an application of the component in preparing anemia-deficiency medicine. Background technique [0002] With the acceleration of the pace of life, people's life is becoming more and more irregular, and the "blood deficiency" mentioned in traditional Chinese medicine is also more and more common in young people. It is a series of diseases caused by blood deficiency caused by various reasons; therefore Finding a reliable drug for treating blood deficiency has important practical significance. [0003] Blood deficiency refers to the pathological phenomenon of loss of yin and blood in the body, which may be caused by excessive blood loss or dysfunction of the spleen and stomach. Chronic blood loss syndrome. Bone marrow stem cells are the main source of hematopoietic ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/258A61K31/704A61P7/06
Inventor 周祥山瞿海斌王毅沈丽娟张淹王春艳张路
Owner SHAN DONG DONG E E JIAO
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