Application of radix dipsaci saponin X in preparation of medicines for preventing or treating pulmonary fibrosis
A technology of Dipsacus saponin and pulmonary fibrosis, which is applied in the field of application of Dipsacus saponin X in the preparation of drugs for preventing or treating pulmonary fibrosis, and can solve the problems of unreported pharmacological effects, etc.
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preparation example 1
[0009] Preparation Example 1: Preparation of Dipsacus saponin X
[0010] Take 1 kg of Dipsacus chuanxiong medicinal material, crush it, pass through a 10-mesh sieve, add 10 times the amount (V / W) of 70% ethanol to soak overnight, reflux extraction twice, each time for 2 hours, filter the extract, and recover the ethanol until it is free. Add water to form a suspension, extract 3 times with n-butanol, combine the lower aqueous layer, apply the sample to the treated D101 macroporous resin (the weight ratio of resin to medicinal material is 1:1), wash 3 column volumes with water, discard Go, then elute 3 column volumes with 30% ethanol, discard, and finally wash 3 column volumes with 50% ethanol, collect the 50% ethanol eluate, concentrate, decolorize with activated carbon, and recrystallize to obtain a content of 98%. Dipsacus saponin X6.5g.
preparation example 2
[0011] Preparation Example 2: Preparation of Dipsacus saponin X
[0012] Take 1 kg of Dipsacus chuanxiong medicinal material, crush it, pass through a 10-mesh sieve, add 10 times the amount (V / W) of 70% ethanol to soak overnight, reflux extraction twice, each time for 2 hours, and recover the ethanol from the extract until it has no alcohol smell , add ethanol to the concentrated solution until the alcohol concentration is 80%, let it stand overnight; filter it with suction, concentrate the filtrate until it has no alcohol smell, add 5 times the amount of water, let it stand overnight, filter it with suction, and load the filtrate on the treated D101 macroporous resin (The weight ratio of resin to medicinal material is 1:1), washed with 0.5% sodium hydroxide solution for 2 column volumes and then washed with water until neutral, then eluted with 30% ethanol for 3 column volumes, discarded, and finally washed with 50% ethanol 3 column volumes, collect the 50% ethanol eluate, co...
Embodiment 3
[0013] Example 3 Preparation of Dipsacus saponin X tablet
[0014] Weigh 50.0g Dipsacapsaponin X, 55.0g powdered sugar, 70.0g lactose and 23.0g sodium carboxymethyl starch, mix well and pass through a 100-mesh sieve, add an appropriate amount of 3% PVP K30 Appropriate amount of water solution to make soft material, granulate with 20-mesh sieve, dry at 60°C for 3 hours, granulate with 18-mesh sieve, add 2.0g of magnesium stearate, mix evenly, punch with shallow concave, and adjust the tablet weight to about 200mg.
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