Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Application of radix dipsaci saponin X in preparation of medicines for preventing or treating pulmonary fibrosis

A technology of Dipsacus saponin and pulmonary fibrosis, which is applied in the field of application of Dipsacus saponin X in the preparation of drugs for preventing or treating pulmonary fibrosis, and can solve the problems of unreported pharmacological effects, etc.

Active Publication Date: 2014-03-12
安徽格太信控科技有限公司
View PDF2 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Dipsacus saponin X is extracted from Dipsacus and is the active ingredient of Dipsacus, but the pharmacological effects of Dipsacus saponin X in the preparation of prevention or treatment of pulmonary fibrosis have not been reported

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of radix dipsaci saponin X in preparation of medicines for preventing or treating pulmonary fibrosis

Examples

Experimental program
Comparison scheme
Effect test

preparation example 1

[0009] Preparation Example 1: Preparation of Dipsacus saponin X

[0010] Take 1 kg of Dipsacus chuanxiong medicinal material, crush it, pass through a 10-mesh sieve, add 10 times the amount (V / W) of 70% ethanol to soak overnight, reflux extraction twice, each time for 2 hours, filter the extract, and recover the ethanol until it is free. Add water to form a suspension, extract 3 times with n-butanol, combine the lower aqueous layer, apply the sample to the treated D101 macroporous resin (the weight ratio of resin to medicinal material is 1:1), wash 3 column volumes with water, discard Go, then elute 3 column volumes with 30% ethanol, discard, and finally wash 3 column volumes with 50% ethanol, collect the 50% ethanol eluate, concentrate, decolorize with activated carbon, and recrystallize to obtain a content of 98%. Dipsacus saponin X6.5g.

preparation example 2

[0011] Preparation Example 2: Preparation of Dipsacus saponin X

[0012] Take 1 kg of Dipsacus chuanxiong medicinal material, crush it, pass through a 10-mesh sieve, add 10 times the amount (V / W) of 70% ethanol to soak overnight, reflux extraction twice, each time for 2 hours, and recover the ethanol from the extract until it has no alcohol smell , add ethanol to the concentrated solution until the alcohol concentration is 80%, let it stand overnight; filter it with suction, concentrate the filtrate until it has no alcohol smell, add 5 times the amount of water, let it stand overnight, filter it with suction, and load the filtrate on the treated D101 macroporous resin (The weight ratio of resin to medicinal material is 1:1), washed with 0.5% sodium hydroxide solution for 2 column volumes and then washed with water until neutral, then eluted with 30% ethanol for 3 column volumes, discarded, and finally washed with 50% ethanol 3 column volumes, collect the 50% ethanol eluate, co...

Embodiment 3

[0013] Example 3 Preparation of Dipsacus saponin X tablet

[0014] Weigh 50.0g Dipsacapsaponin X, 55.0g powdered sugar, 70.0g lactose and 23.0g sodium carboxymethyl starch, mix well and pass through a 100-mesh sieve, add an appropriate amount of 3% PVP K30 Appropriate amount of water solution to make soft material, granulate with 20-mesh sieve, dry at 60°C for 3 hours, granulate with 18-mesh sieve, add 2.0g of magnesium stearate, mix evenly, punch with shallow concave, and adjust the tablet weight to about 200mg.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides a new application of radix dipsaci saponin X in the preparation of medicines, and particularly relates to an application of the radix dipsaci saponin X in the inhibition of occurrence and development of pulmonary fibrosis by inhibiting epithelial intercellular substance transition and fibroblast proliferation so as to prevent or treat pulmonary fibrosis. In the application, the dosage of the radix dipsaci saponin X is in the range of 50-2000mg, preferably 50-1000mg.

Description

technical field [0001] The present invention relates to Dipsacus saponin X inhibiting the occurrence and development of pulmonary fibrosis so as to prevent or treat pulmonary fibrosis; specifically, Dipsacapsaponin X inhibits pulmonary fibrosis by inhibiting epithelial-mesenchymal transition (EMT) and inhibiting abnormal activation of pulmonary fibroblasts. The occurrence and development of fibrosis can prevent or treat pulmonary fibrosis. Background technique: [0002] Idiopathic pulmonary fibrosis (IPF), also known as cryptogenic fibrosing alveolitis (CFA), is a chronic inflammatory interstitial disease. (usual interstitialpneumonia, UIP) is a characteristic pathological change with unknown etiology. The main manifestations are that the appearance of fibroblastic foci leads to the deposition of a large amount of extracellular matrix (ECM), the accumulation of collagen, and the destruction of alveolar structure, which eventually leads to the destruction of normal lung tiss...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K31/704A61P11/00
Inventor 蒋王林吕长俊栾海云亢泽春
Owner 安徽格太信控科技有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products