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Application of a kind of extract of radix oleifera in the preparation of medicine for treating leukemia

A kind of technology of Alpinia chinensis and extract, which can be applied in the field of medicine and can solve the problems such as the drug report of Alpinia chinensis leukemia that has not been seen yet.

Inactive Publication Date: 2015-08-12
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The above-mentioned documents and patents, etc., have not yet seen the report of the radix radix or the extract of the radix radix being used for the preparation of the medicine for the treatment of leukemia

Method used

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  • Application of a kind of extract of radix oleifera in the preparation of medicine for treating leukemia
  • Application of a kind of extract of radix oleifera in the preparation of medicine for treating leukemia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Embodiment 1: the preparation of radix oleifera extract

[0036] (1) 26kg of white flower vine, crushed, passed through a 30-mesh sieve, using supercritical carbon dioxide extraction technology, extraction temperature 45 ℃, extraction pressure 25MPa, extraction time 2h, extracting volatile oil, collecting volatile oil, that is the white flower vine extract A, Baihuayoumateng medicinal residue A after supercritical carbon dioxide extraction;

[0037] (2) Use 80% ethanol as the solvent to extract the white-flowered oil-matto medicinal residue A obtained in step (1) by warm soaking at 70°C. It is 12 times of the weight of radix radiata, and is filtered to obtain medicinal residue B and extract, and the extract is recovered with ethanol, concentrated, and dried to obtain radix radix extract B;

[0038] (3) Extract the dregs B obtained in step (2) by adding water to reflux. The number of extractions is 2 times, and the extraction time is 2 hours each time. The amount of wat...

Embodiment 2

[0040] Embodiment 2: the preparation of the extract of radix oleifera

[0041] (1) 20kg of white-flowered vine, crushed, passed through a 10-mesh sieve, using supercritical carbon dioxide extraction technology, extraction temperature 40-℃, extraction pressure 20MPa, extraction time 1h, extracting volatile oil, collecting volatile oil, that is, white-flowered vine extract Matter A, the white flower oil Mateng medicinal residue A after supercritical carbon dioxide extraction;

[0042] (2) Use 70% ethanol as a solvent to extract the Baihuayoumateng medicinal residue A obtained in step (1) by warm soaking at 50°C. The number of extractions is 2 times, and the extraction time for each time is 1 hour. It is 10 times of the weight of radix radiata, and is filtered to obtain medicinal residues B and an extract, and the extract is recovered with ethanol, concentrated, and dried to obtain radix radix extract B;

[0043] (3) Extract the dregs B obtained in step (2) by adding water to re...

Embodiment 3

[0045] Embodiment 3: the preparation of the extract of radix oleifera

[0046] (1) 19kg of radix oleifera, crushed, passed through a 50-mesh sieve, using supercritical carbon dioxide extraction technology, extraction temperature 50 ℃, extraction pressure 30MPa, extraction time 2h, extracting volatile oil, collecting volatile oil, that is variegated lentil extract A, Baihuayoumateng medicinal residue A after supercritical carbon dioxide extraction;

[0047] (2) Use 95% ethanol as a solvent to extract the white-flowered oil-matto medicinal residue A obtained in step (1) by warm soaking at 80°C. The number of extractions is 4 times, and the extraction time for each time is 3 hours. The amount of solvent used each time is It is 15 times of the weight of radix radiata, and is filtered to obtain medicinal residue B and an extract, and the extract is recovered with ethanol, concentrated, and dried to obtain radix radix extract B;

[0048] (3) Extract the dregs B obtained in step (2)...

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Abstract

The invention discloses a novel application of mucuna birdwoodiana extract, namely an application of the mucuna birdwoodiana extract in the preparation of drugs for treating leukemia. The mucuna birdwoodiana extract is prepared by the following steps: taking mucuna birdwoodiana as the raw material, then extracting the raw material by adopting a supercritical carbon dioxide extracting technology, purifying the extract by adopting a macroporous resin purifying technology so as to obtain a mucuna birdwoodiana extract A, a mucuna birdwoodiana extract B, and a mucuna birdwoodiana extract C, and mixing the three extracts according to a certain ratio so as to obtain the mucuna birdwoodiana extract. The mucuna birdwoodiana extract provided by the invention has an important meaning in the preparation of drugs for treating leukemia.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to the application of an extract of traditional Chinese medicinal materials in the preparation of medicines for treating leukemia, in particular to the application of an extract of radix radix L. radiata in the preparation of medicines for treating leukemia. Background technique [0002] Leukemia is a malignant disease that originates from the hematopoietic system and is characterized by the production and accumulation of a large number of immature and abnormal white blood cells in the bone marrow or other hematopoietic tissues. From the perspective of form, most leukemia cells are immature and abnormally morphological white blood cells; in terms of function, leukemia cells have the same characteristics as tumor cells: leukemia cells are tumorous proliferation, which cannot be controlled, and often leads to the inhibition and failure of bone marrow hematopoietic function. It can cause anemia, ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/48A61K45/00A61P35/02A61K131/00
Inventor 程光惠毛锦程武宁
Owner JILIN UNIV
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