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Application of mucuna birdwoodiana extract in preparation of drugs for treating leukemia

A kind of technology of Alpinia chinensis and extract, which can be applied in the field of medicine and can solve the problems such as the drug report of Alpinia chinensis leukemia that has not been seen yet.

Inactive Publication Date: 2014-03-05
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The above-mentioned documents and patents, etc., have not yet seen the report of the radix radix or the extract of the radix radix being used for the preparation of the medicine for the treatment of leukemia

Method used

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  • Application of mucuna birdwoodiana extract in preparation of drugs for treating leukemia
  • Application of mucuna birdwoodiana extract in preparation of drugs for treating leukemia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Example 1: Preparation of Radix chinensis extract

[0036] (1) 26kg of Radix vulgaris, crushed, passed through a 30-mesh sieve, using supercritical carbon dioxide extraction technology, extraction temperature 45°C, extraction pressure 25MPa, extraction time 2h, extract volatile oil, and collect the volatile oil, that is, the extract of Radix Radix et al. A, after the extraction of supercritical carbon dioxide, the medicinal residues A of A.

[0037] (2) Using 80% ethanol as a solvent, the medicinal residue A obtained in step (1) was warmly soaked and extracted at 70 ° C, the extraction times were 2 times, the extraction time was 2 hours each time, and the amount of solvent each time was 2 hours. It is 12 times of the weight of Alpinia chinensis, filtered to obtain medicinal residues B and an extract, and the extract reclaims ethanol, concentrated, and dried to obtain Alpinia chinensis extract B;

[0038] (3) The medicinal residue B obtained in step (2) is extracted by ...

Embodiment 2

[0040] Example 2: Preparation of Radix chinensis extract

[0041] (1) 20kg of Radix vulgaris, crushed, passed through a 10-mesh sieve, using supercritical carbon dioxide extraction technology, extraction temperature 40-℃, extraction pressure 20MPa, extraction time 1h, extract volatile oil, and collect volatile oil, that is, the extraction of Radix Radix et Rhizoma Substance A, after the extraction of supercritical carbon dioxide, the medicinal residues A of A.

[0042] (2) Using 70% ethanol as a solvent, the medicinal residue A obtained in step (1) was warmly soaked and extracted at 50 ° C, the extraction times were 2 times, the extraction time was 1 hour each time, and the amount of solvent each time was 1 hour. It is 10 times of the weight of Fructus chinensis, filtered to obtain medicinal residues B and extract, the extracting solution reclaims ethanol, concentrated, and dried to obtain Fructus chinensis extract B;

[0043] (3) The medicinal residue B obtained in step (2) ...

Embodiment 3

[0045] Example 3: Preparation of Radix chinensis extract

[0046] (1) 19kg of Radix chinensis, crushed, passed through a 50-mesh sieve, using supercritical carbon dioxide extraction technology, extraction temperature 50°C, extraction pressure 30MPa, extraction time 2h, extract volatile oil, collect volatile oil, that is, Radix Radix et Rhizoma extract A, after the extraction of supercritical carbon dioxide, the medicinal residues A of A.

[0047] (2) Using 95% ethanol as a solvent, the medicinal residue A obtained in step (1) was warmly soaked and extracted at 80° C. The extraction times were 4 times, and the extraction time was 3 hours each time, and the amount of solvent each time was 3 hours. It is 15 times of the weight of Alpinia chinensis, filtered to obtain medicinal residues B and an extract, and the extract reclaims ethanol, concentrated, and dried to obtain Alpinia chinensis extract B;

[0048] (3) The medicinal residue B obtained in step (2) is extracted by adding ...

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Abstract

The invention discloses a novel application of mucuna birdwoodiana extract, namely an application of the mucuna birdwoodiana extract in the preparation of drugs for treating leukemia. The mucuna birdwoodiana extract is prepared by the following steps: taking mucuna birdwoodiana as the raw material, then extracting the raw material by adopting a supercritical carbon dioxide extracting technology, purifying the extract by adopting a macroporous resin purifying technology so as to obtain a mucuna birdwoodiana extract A, a mucuna birdwoodiana extract B, and a mucuna birdwoodiana extract C, and mixing the three extracts according to a certain ratio so as to obtain the mucuna birdwoodiana extract. The mucuna birdwoodiana extract provided by the invention has an important meaning in the preparation of drugs for treating leukemia.

Description

technical field [0001] The invention belongs to the field of medicine and relates to the application of a Chinese medicinal material extract in the preparation of a drug for treating leukemia, in particular to the application of an extract of A. chinensis in the preparation of a drug for treating leukemia. Background technique [0002] Leukemia is a malignant disease of hematopoietic origin and characterized by the production and accumulation of large numbers of immature and abnormal white blood cells in the bone marrow or other hematopoietic tissues. In terms of form, most leukemia cells are immature and morphologically abnormal leukocytes; in function, leukemia cells have the same characteristics as tumor cells: leukemia cells are tumor-proliferating and uncontrollable, often leading to inhibition and failure of bone marrow hematopoietic function. The patient suffers from anemia, neutropenia and thrombocytopenia, and leukemia cells can infiltrate various tissues and organs...

Claims

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Application Information

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IPC IPC(8): A61K36/48A61K45/00A61P35/02A61K131/00
Inventor 孔倩倩
Owner JILIN UNIV
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