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A kind of preparation method and application of Artemisia arborii extract

A technology of Artemisia arborii extract and Artemisia arborii, applied in the field of biomedicine, can solve the problems that have not yet been reported on Artemisia arborescens or Artemisia arborii extract, and achieve a significant anti-tuberculosis effect

Inactive Publication Date: 2016-05-18
TAISHAN MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The above-mentioned documents and patents, etc., have not yet seen the report of Artemisia arborii or the extract of Artemisia arborii for the preparation of drugs for the treatment of tuberculosis

Method used

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  • A kind of preparation method and application of Artemisia arborii extract
  • A kind of preparation method and application of Artemisia arborii extract
  • A kind of preparation method and application of Artemisia arborii extract

Examples

Experimental program
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Effect test

Embodiment 1

[0034] Embodiment 1: Preparation of Artemisia arborii extract

[0035] (1) 30kg of Artemisia arborii, first use 95% ethanol as a solvent, heat and reflux extraction, the number of extractions is 3 times, each extraction time is 2 hours, the amount of solvent each time is 12 times the weight of Artemisia arrenae, filter , to obtain the dregs A and the extract, recover the ethanol from the extract, concentrate, and dry to obtain the Artemisia arborii extract A;

[0036] (2) Use the dregs A obtained in step (1) with water as a solvent, heat and reflux extraction, the number of extractions is 2 times, each extraction time is 2 hours, and the amount of solvent used each time is 12 times the weight of Artemisia arborifolia, filtered, Concentrate the extract to a relative density of d=1.11, filter to obtain medicinal solution B;

[0037] (3) Pass the drug solution B obtained in step (2) through the D101 non-polar macroporous adsorption resin column, and first elute with water, and t...

Embodiment 2

[0039]Embodiment 2: Preparation of Artemisia arborii extract

[0040] (1) 18kg of Artemisia arborii, first use 80% ethanol as a solvent, heat and reflux extraction, the number of extractions is 1 time, each extraction time is 4 hours, and the amount of solvent used each time is 15 times the weight of Artemisia arrenae, filtered , to obtain the dregs A and the extract, recover the ethanol from the extract, concentrate, and dry to obtain the Artemisia arborii extract A;

[0041] (2) Use 10% ethanol as a solvent to extract the dregs A obtained in step (1), heat and reflux for extraction, the number of extractions is 3 times, each extraction time is 1 hour, and the amount of solvent used each time is 8 times the weight of Artemisia argentina , filtered, the extract recovered ethanol, concentrated to a relative density of d=1.12, filtered to obtain medicinal solution B;

[0042] (3) Pass the drug solution B obtained in step (2) through the AB-8 non-polar macroporous adsorption res...

Embodiment 3

[0044] Embodiment 3: Preparation of Artemisia arborii extract

[0045] (1) 20kg of Artemisia arrenae, first use 100% ethanol as a solvent, heat and reflux extraction, the number of extractions is 3 times, each extraction time is 1 hour, each time the amount of solvent is 8 times the weight of Artemisia arrenae, filter, Obtain the dregs A and the extract, recover ethanol from the extract, concentrate, and dry to obtain the Artemisia arborii extract A;

[0046] (2) Use 20% ethanol as a solvent to extract the dregs A obtained in step (1), heat and reflux for extraction, the number of extractions is 1 time, each extraction time is 4 hours, and the amount of solvent used each time is 15 times the weight of Artemisia arrenae , filtered, the extract recovered ethanol, concentrated to relative density d=1.10, filtered to obtain liquid B;

[0047] (3) Pass the drug solution B obtained in step (2) through a D101 non-polar macroporous adsorption resin column, and first elute with water,...

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Abstract

The invention relates to a preparation method and application of an artemisia adamsii besser extract. The preparation method is as follows: extracting artemisia adamsii besser to obtain an artemisia adamsii besser extract A, an artemisia adamsii besser extract B and an artemisia adamsii besser extract C by two times of macroporous adsorption resin purification, mixing the artemisia adamsii besser extract A, the artemisia adamsii besser extract B and the artemisia adamsii besser extract C in a certain ratio to obtain the artemisia adamsii besser extract. The artemisia adamsii besser extract can be combined with a pharmaceutical acceptable carrier or other appropriate excipient to be prepared, by a routine method, into an orally administrated preparation formulation, and can be used in preparation of drugs for treatment of pulmonary tuberculosis.

Description

technical field [0001] The invention belongs to the field of biomedicine, and relates to a preparation method and application of an extract of Chinese medicinal materials, in particular to a preparation method of an Artemisia arborii extract and its application in the preparation of medicines for treating pulmonary tuberculosis. Background technique [0002] Tuberculosis is a chronic infectious disease caused by Mycobacterium tuberculosis invading the body under certain conditions. At present, the situation of global tuberculosis prevention and control is severe. In 2006, there were 9.2 million new tuberculosis cases in the world, and 1.7 million people died of tuberculosis in 2006. The treatment of pulmonary tuberculosis is mainly based on chemotherapy. In recent years, research on tuberculosis immunology has made great strides, enabling people to have a more comprehensive understanding of the onset, clinical course, prognosis and recurrence of tuberculosis. Due to the upd...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/28A61K9/20A61K9/16A61K9/48A61P31/06A61P11/00
Inventor 蒋晓琴王红艳
Owner TAISHAN MEDICAL UNIV
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