A device and method for continuous rapid reaction crystallization to improve crystal stability

Abstract

The invention discloses a device and method for improving stability of crystals by using continuous and rapid reactive crystallization. The device comprises a kettle-type reactor and a tubular reactor connected with the kettle-type reactor in series, wherein the kettle-type reactor is internally provided with a liquid jet impacting feeding device; the liquid jet impacting feeding device comprises a hollow pipe and more than two feeding pipes, and the pipe wall of the hollow pipe is provided with a through hole through which the feeding pipes pass; the feeding pipes are inserted from an upper port of the hollow pipe and can go out from the through hole in the pipe wall, discharge openings of the feeding pipes are connected with nozzles, and the discharge opening and / or nozzle of each feeding pipe is fixed at the lower end part of the hollow pipe through a fixing frame; the nozzles are arranged in a specific way to ensure compacting collision, and a feeding pipe section between the through hole in the hollow pipe and the fixing frame is of an arc-shaped structure. The device and the method provided by the invention have the advantages that the average size and granularity of the crystals are uniform, and the purity and stability of a product are greatly improved.

Description

technical field [0001] The invention belongs to the technical field of chemical and pharmaceutical crystallization, and in particular relates to a device and method for continuous rapid reaction crystallization to improve crystal stability. Background technique [0002] The crystallization process, as an important basic production process, is widely used in various industrial fields. Therefore, the quality of the crystals produced has a significant impact on downstream processes such as filtration, grinding and drying, as well as transport and storage. [0003] Stability is an important consideration for many pharmaceutical crystalline compounds. It is well known that most of the crystalline pharmaceutical compounds obtained through the reaction crystallization process contain both crystalline and amorphous structures. Crystal structure, because of its lower internal free energy can make the drug more stable. Changes in a drug's crystalline form can not only affect its ap...

AI Technical Summary

Problems solved by technology

This unequal residence time of reactants and products, in addition to reducing yields, can lead to non-uniform crystal size distribution

For some drugs that degrade during the reaction, in extreme cases, different residence times may lead to substantial degradation of the product during production

[0008] Third, intermittent operations require regular downtime

For example, the reaction process and the crystallization process still occur simultaneously in the same container, and a uniform residence time cannot be guaranteed.

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