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Tissue-engineered artificial bone and building method thereof

A technology of tissue engineering and artificial bone, which is applied in the field of repairing bone defect materials and its construction. It can solve the problems of low mechanical strength and fragility of CPC, and achieve the effects of high strength, convenient operation and low cost.

Active Publication Date: 2014-01-22
XIANGYA HOSPITAL CENT SOUTH UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, traditional CPC is fragile and has low mechanical strength, so it can only be used in bone tissue in non-load-bearing areas, so its mechanical properties need to be improved

Method used

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  • Tissue-engineered artificial bone and building method thereof

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Embodiment 1

[0023] The collagen suture-CPC composite material of the present invention is composed of collagen suture, TTCP and DCPA. The strength of the CPC can be changed by adjusting the ratio of the collagen suture, and finally the stem cells are seeded on the collagen suture-CPC composite material to construct tissue engineered artificial bone.

[0024] The construction steps of the tissue engineered artificial bone of the present embodiment are as follows:

[0025] (1) Preparation of collagen suture-CPC composite material

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Abstract

The invention discloses a tissue-engineered artificial bone and a building method thereof. According to the artificial bone, human umbilical cord mesenchymal stem cells, (human umbilical cord mesenchymal stem cells, hUCMSCs) are inoculated on a collagen suture line-CPC composite material, wherein CPC is prepared from tetracalcium phosphate (tetracalcium phosphate, TTCP) and dicalcium phosphate anhydrous (dicalcium phosphate anhydrous, DCPA) (TTCP and DCPA are mixed according to the molar ratio of 1 / 1); the collagen suture line and CPC powder are evenly mixed according to different volume ratios, and then the mixture is mixed with deionized water according to the mass ratio of (3-5) / 1; finally, the hUCMSCs are inoculated on the collagen suture line-CPC composite material. The artificial bone prepared by the method is high in strength, and strong in ability of repairing bone defects.

Description

technical field [0001] The invention belongs to the technical field of surgical materials, and in particular relates to a material for repairing bone defects and a construction method thereof, in particular to a tissue-engineered artificial bone constructed from umbilical cord blood stem cells and collagen suture-CPC composite materials and a construction method thereof. Background technique [0002] Human bone marrow mesenchymal stem cells have the potential to differentiate into different tissues, such as bone, cartilage and muscle. Human bone marrow mesenchymal stem cells can be derived from the patient's bone marrow, expanded in vitro, induced to differentiate, and seeded on biological scaffolds to repair bone defects. Therefore, tissue engineered artificial bone based on stem cells has shown great potential in bone defect and bone regeneration. Moreover, there are currently a large number of patients with bone defect who need surgical treatment. The clinical use of tiss...

Claims

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Application Information

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IPC IPC(8): A61L27/38A61L27/24A61L27/12
Inventor 胡建中吕红斌周永春
Owner XIANGYA HOSPITAL CENT SOUTH UNIV
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