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Preparation method of magnetic Fe3O4@SiO2-NH2 nanoparticles

A technology of fe3o4sio2-nh2 and nano-microspheres, which is applied to the magnetic properties of inorganic materials, fixed on or in the inorganic carrier, and can solve the problems of magnetic nanoparticle agglomeration and other problems

Inactive Publication Date: 2013-11-20
YELLOW SEA FISHERIES RES INST CHINESE ACAD OF FISHERIES SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the presence of an external magnetic field, the magnetic nanoparticles will obtain a dipole moment, and the dipole moment-dipole moment interaction will cause the magnetic nanoparticles to form a chain and cross-linked structure, resulting in the agglomeration of the magnetic nanoparticles.

Method used

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  • Preparation method of magnetic Fe3O4@SiO2-NH2 nanoparticles
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  • Preparation method of magnetic Fe3O4@SiO2-NH2 nanoparticles

Examples

Experimental program
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Effect test

Embodiment 1

[0052] 1) Magnetic Fe 3 o 4 Synthesis of Nanospheres:

[0053] A certain amount of water (similar to the size of the container) was added into a round bottom flask, the reaction system was protected by argon, and the oxygen in the water was removed by the vacuum deaeration method with the help of liquid nitrogen, and 4.0g FeCl 2 4H 2 O and 10.8 g FeCl 3 ·6H 2 O in the container, protected by argon, heated to 80°C, after the reaction system is uniform, add 29wt% 50ml ammonia solution drop by drop to turn black, continue to heat for 20-30min, magnetically adsorb, and then repeat with distilled water and absolute ethanol Wash several times until the washing solution is neutral, and evaporate to dryness to obtain the black product Magnetic Fe 3 o 4 Nanoparticles (MNPs).

[0054] 2) Magnetic Fe 3 o 4 SiO 2 Synthesis of Nanospheres:

[0055] The magnetic Fe of step 1) 3 o 4 Put 1.0g of nanospheres in a 250ml two-neck flask, add 80ml of absolute ethanol, and 20ml of wate...

Embodiment 2

[0059] 1) Magnetic Fe 3 o 4 Synthesis of Nanospheres:

[0060] A certain amount of water (similar to the size of the container) was added into a round bottom flask, the reaction system was protected by argon, and the oxygen in the water was removed by the vacuum deaeration method with the help of liquid nitrogen, and 3.5gFeCl 2 4H 2 O and 9.45gFeCl 3 ·6H 2 O in the container, protected by argon, heated to 70°C, after the reaction system is uniform, add 29wt% 37.5ml ammonia solution drop by drop to turn black, continue heating for 20min, magnetic adsorption, and then wash repeatedly with distilled water and absolute ethanol Several times until the washing solution is neutral, evaporate to dryness to obtain a black product, magnetic Fe 3 o 4 Nanoparticles (MNPs).

[0061] 2) Magnetic Fe 3 o 4 SiO 2 Synthesis of Nanospheres:

[0062] The magnetic Fe of step 1) 3 o 4 Put 0.1g of nanospheres into a 250ml two-necked flask, add 80ml of absolute ethanol, and 20ml of water...

Embodiment 3

[0066] 1) Add a certain amount of water (similar to the size of the container) into the round bottom flask, protect the reaction system with argon gas, use liquid nitrogen to freeze and thaw repeatedly, remove oxygen in the water by vacuum deaeration method, and dissolve 4.5gFeCl 2 4H 2 O and 12.15 g FeCl 3 ·6H 2 O in the container, protected by argon, heated to 90°C, after the reaction system is uniform, add 29wt% 62.5ml ammonia solution drop by drop to turn black, continue heating for 20-30min, magnetic adsorption, and then use distilled water and absolute ethanol respectively Repeated washing several times until the washing liquid is neutral, evaporated to dryness, and obtained the black product magnetic Fe 3 o 4 Nanoparticles (MNPs).

[0067] 2) Magnetic Fe 3 o 4 SiO 2 Synthesis of Nanospheres:

[0068] The magnetic Fe of step 1) 3 o 4 Put 1.5g of nanospheres into a 250ml two-neck flask, add 80ml of absolute ethanol, and 20ml of water, stir for 10min under argon ...

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Abstract

The invention relates to a preparation method of magnetic Fe3O4@SiO2-NH2 nanoparticles. The preparation method of the magnetic Fe3O4@SiO2-NH2 nanoparticles comprises the step of synthesizing of magnetic Fe3O4 nanoparticles, magnetic Fe3O4@SiO2 nanoparticles and the magnetic Fe3O4@SiO2-NH2 nanoparticles, wherein the magnetic Fe3O4 nanoparticles are spherical, even in particle size and good in dispersibility, the particle sizes of the magnetic Fe3O4 nanoparticles are 5-10 nm, and the heat stability is good. The magnetic Fe3O4@SiO2-NH2 nanoparticles are good in crystal structure, have unique magnetic property and can be used in various biotechnological fields such as magnetofluid, contrast agents, immunodetection, cell separation, biosensors, separation and purification of protein and nucleic acid, diagnostic reagents and enzyme immobilization.

Description

technical field [0001] The invention relates to the field of magnetic materials, in particular to a magnetic Fe 3 o 4 SiO 2 -NH 2 The preparation method of nano microsphere Background technique [0002] Magnetic nanomaterials are a new type of magnetic material with unique physical and chemical properties, such as small particle size between 1-100nm, large specific surface area, good magnetic properties, and easy addition of some biological functional groups. Therefore, it has a wide range of uses in practical applications and is widely used in various fields of biotechnology, such as the preparation of immobilized enzymes, the separation and purification of proteins and nucleic acids, and the like. In recent years, the research on the preparation methods of magnetic nanomaterials has been paid great attention by scholars. Among them, the chemical co-precipitation method has the advantages of low cost, high yield and easy surface treatment. The particle size of magnetic...

Claims

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Application Information

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IPC IPC(8): H01F1/11H01F1/36C12N11/14
Inventor 徐甲坤孙谧盛军刘均忠郑鸿飞
Owner YELLOW SEA FISHERIES RES INST CHINESE ACAD OF FISHERIES SCI
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