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Compound traditional Chinese medicine for treating depression

A compound traditional Chinese medicine, depression technology, applied in the field of medicine, can solve the problems of easy recurrence, high drug price, large toxic and side effects, etc.

Active Publication Date: 2013-10-30
HUNAN UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] For the treatment of depression, Western medicine currently uses 5-hydroxytryptamine reuptake inhibitors, monoamine oxidase inhibitors, phenylpyrazine derivatives, 5-hydroxytryptamine-norepinephrine reuptake inhibitors, aminoketones, tricyclics, Seven types of antidepressants such as tetracycline pyrazine azepines, but most of the synthetic antidepressants have defects such as narrow antidepressant spectrum, large toxic and side effects, high drug price and easy relapse

Method used

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  • Compound traditional Chinese medicine for treating depression
  • Compound traditional Chinese medicine for treating depression
  • Compound traditional Chinese medicine for treating depression

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Example 1 Granule dosage form of the pharmaceutical composition of the present invention

[0018] Using the conventional method of preparing granules, take 3 parts of peony, 2.4 parts of Anemarrhena, 1.2 parts of turmeric, 0.9 parts of Hypericum perforatum, 1.8 parts of Bupleurum, 1.8 parts of perilla, and 0.3 parts of long pepper, soak in water for 0.5 hours and extract twice. The amount of water added is 10 times and 8 times respectively, the first extraction is 2 hours, the second extraction is 1.5 hours, filtering, combining the filtrate, concentrating, drying, pulverizing, adding appropriate amount of auxiliary materials, mixing, granulating, sieving, drying, A granular pharmaceutical composition preparation is prepared.

Embodiment 2

[0019] Example 2 Tablet form of the pharmaceutical composition of the present invention

[0020] Using the conventional method of preparing tablets, take 0.8 part of peony, 1 part of Anemarrhena, 0.3 part of turmeric, 0.2 part of Hypericum perforatum, 0.5 part of Bupleurum, 0.5 part of perilla, 0.5 part of long pepper, soak in water for 0.5 hour and extract twice , The amount of water added is 6 times and 4 times respectively, the first extraction is 2 hours, the second extraction is 1 hour, filter, combine the filtrate, add appropriate amount of auxiliary materials after concentration, drying, crushing, mixing, granulating, sieving, drying , The prepared granules are further compressed and dried to prepare a pharmaceutical composition preparation in tablet dosage form.

Embodiment 3

[0021] Example 3 The capsule dosage form of the pharmaceutical composition of the present invention

[0022] Using the conventional method of preparing capsules, take 2 parts of peony, 1.5 parts of Anemarrhena, 1 part of turmeric, 0.6 parts of Hypericum perforatum, 1.5 parts of Bupleurum, 1.5 parts of perilla, 1 part of long pepper, and soak in 60% ethanol for 0.5 hours. Extract 2 times, the amount of water added is 7 times and 5 times respectively, the first extraction is 2 hours, the second extraction is 1 hour, filter, combine the filtrate, add appropriate amount of auxiliary materials after concentration, drying and crushing, mix well, granulate, and pass Sieve, dry, and put the prepared granules into a capsule shell to prepare a capsule, that is, a pharmaceutical composition preparation in a capsule dosage form.

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Abstract

The invention discloses a compound traditional Chinese medicine for treating depression. The compound traditional Chinese medicine taking Chinese herbaceous peony, radix bupleurim, turmeric, hyperforin perforatum, purple perilla, rhizoma anemarrhenae and long pepper as raw materials is extracted and separated by 0-75% ethanol and prepared as medically acceptable oral preparations such as troches, capsules (soft or hard capsules) and particles. The drafted major functions of the compound traditional Chinese medicine are soothing liver-qi stagnation and dispersing blood stasis and dredging collateral, and the compound traditional Chinese medicine is used for treating mild-to-moderate depression. The pharmacological researches show that the pharmaceutical composition can remarkably enhance open field activity of chronic stress depression mode mice and increase the consumption of sweet water; antagonizes akinesia and hypothermia of chronic stress depression mode mice induced by reserpine, so that the number of autonomic activities of despair animal mode induced by tail suspension and forced swimming and tail suspension and swimming immobility time are increased. The compound traditional Chinese medicine disclosed by the invention with the functions of soothing liver-qi stagnation is an effective special medicine for treating depression.

Description

Technical field [0001] The invention belongs to the technical field of medicine, and relates to a medicine for treating depression, specifically, it is a compound traditional Chinese medicine containing peony, Anemarrhena, turmeric, Hypericum perforatum, Bupleurum, perilla, and long pepper. Background technique [0002] Depression is a common emotional and mental disorder. As the pace of social life accelerates, depression has become a high-incidence disease in today's society. According to statistics from the World Health Organization in 2005, the prevalence of various depressions accounted for about 11% of the global population. According to an epidemiological survey in my country in 2003, there are at least 36 million depression patients in my country, of which only 5% of severe patients receive relevant treatment. Many patients with major depression committed suicide because they did not receive regular treatment in time. According to the analysis of death data in 2003, at ...

Claims

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Application Information

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IPC IPC(8): A61K36/9066A61P25/24
Inventor 王宇红韩远山
Owner HUNAN UNIV OF CHINESE MEDICINE
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