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Method for preparing orifice-opening rhinitis spray

A spray and rhinitis technology, applied in the field of pharmaceutical preparation, can solve the problems of easy outflow, low viscosity, short retention time of medicinal liquid and no curative effect, etc.

Active Publication Date: 2015-01-07
首都儿科研究所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] 1. The injection volume of the liquid medicine is too large and the viscosity is low. It is easy to flow out after spraying into the nasal cavity during use, so the residence time of the liquid medicine in the nasal cavity is too short to achieve the desired curative effect, and the patient's sensitivity during use is not good.
[0005] 2. The finished product is within the validity period (24 months), if it is left standing for too long, the liquid medicine is prone to precipitation

Method used

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  • Method for preparing orifice-opening rhinitis spray

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] 1. Weigh magnolia 14.4kg, add 13 times the volume of water (190L) to soak for 4.5h, distill for 0.5h, extract the aromatic water, collect 6.5kg of aromatic water, and set aside; the distilled aqueous solution is collected in another device, set aside.

[0025] 2. Weigh 1.6kg of Coptis chinensis, add magnolia magnolia dregs, add 4 times the volume of 50% ethanol for the first time, heat and reflux for 1.5h; add 4 times the volume of 50% ethanol for the second time, heat and reflux for 1.0 h; Combine the extracts obtained by the two reflux extractions, filter a total of 115.0 kg, and set aside.

[0026] 3. Recover the ethanol in the above-mentioned extract until there is no alcohol smell.

[0027] 4. Combine the aqueous solution collected in 1 with the ethanol liquid recovered in 3, and concentrate under reduced pressure. During the concentration process, control the vapor pressure within the range of 0.05-0.09MPa. When the relative density of the clear paste reaches 1.01...

Embodiment 2

[0031] 1. Weigh magnolia 14.4kg, add 13 times the volume of water (190L) to soak for 4.5h, distill for 0.5h, extract the aromatic water, collect 6.5kg of aromatic water, and set aside; the distilled aqueous solution is collected in another device, set aside.

[0032] 2. Weigh 1.6kg of Coptis chinensis, add magnolia magnolia dregs, add 4 times the volume of 50% ethanol for the first time, heat and reflux for 1.5h; add 4 times the volume of 50% ethanol for the second time, heat and reflux for 1.0 h; Combine the extracts obtained by the two reflux extractions, filter a total of 115.0 kg, and set aside.

[0033] 3. Recover the ethanol in the above-mentioned extract until there is no alcohol smell.

[0034] 4. Combine the aqueous solution collected in 1 with the ethanol liquid recovered in 3, and concentrate under reduced pressure. During the concentration process, control the vapor pressure within the range of 0.05-0.09MPa. When the relative density of the clear paste reaches 1.01...

Embodiment 3

[0038] 1. Weigh magnolia 14.4kg, add 13 times the volume of water (190L) to soak for 4.5h, distill for 0.5h, extract the aromatic water, collect 6.5kg of aromatic water, and set aside; the distilled aqueous solution is collected in another device, set aside.

[0039] 2. Weigh 1.6kg of Coptis chinensis, add magnolia magnolia dregs, add 4 times the volume of 50% ethanol for the first time, heat and reflux for 1.5h; add 4 times the volume of 50% ethanol for the second time, heat and reflux for 1.0 h; Combine the extracts obtained by the two reflux extractions, filter a total of 115.0 kg, and set aside.

[0040] 3. Recover the ethanol in the above-mentioned extract until there is no alcohol smell.

[0041] 4. Combine the aqueous solution collected in 1 with the ethanol liquid recovered in 3, and concentrate under reduced pressure. During the concentration process, control the vapor pressure within the range of 0.05-0.09MPa. When the relative density of the clear paste reaches 1.01...

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Abstract

The invention discloses a method for preparing an orifice-opening rhinitis spray, which is characterized by comprising the steps of: extracting magnolia flower with water, collecting aromatic water, extracting residues of coptis rhizome and magnolia flower with alcohol to obtain a clear cream, preparing a Carbomer 940 colloidal solution and adding a sodium hydroxide solution, passing through a colloid mill, mixing liquid, metering volume and stirring to obtain the product. The beneficial effects of the invention are that: as the Carbopol 940 colloidal solution is added in the process, the viscosity of the liquid is remarkably increased, the amount of precipitation is reduced, the residence time in a nasal cavity is extended, the sodium hydroxide in the Carbomer 940 colloidal solution not only increases the viscosity of Carbomer 940, but also adjusts the PH value of the liquid (the finished product is tested and the PH is 5.48), a stable phase within a legal range is extended, passing the clear cream through the colloid mill is conductive to grounding insoluble substances in the clear cream, therefore the clear cream is well mixed with Carbomer 940 colloidal solution to form a suspension and the amount of precipitation is effectively reduced.

Description

technical field [0001] The invention relates to a preparation method of a spray, in particular to a preparation method of a Tongqiao rhinitis spray, which belongs to the field of medicament preparation. Background technique [0002] Tongqiao rhinitis spray is a kind of nasal medicine, which has the functions of clearing away heat, clearing away swelling, and relieving pain. It is mainly used for symptoms such as nasal congestion, runny nose, sneezing, redness and swelling of nasal mucosa caused by colds and colds. [0003] Previously, due to the formula, the product had some problems in terms of properties. According to the feedback from patients and the observation of reserved product samples, it was found that the product had the following problems: [0004] 1. The injection volume of the liquid medicine is too large and the viscosity is low. When it is sprayed into the nasal cavity, it is easy to flow out. Therefore, the residence time of the liquid medicine in the nasal ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/12A61K36/718A61K47/32A61P11/02A61P29/00
Inventor 凌科童立芬
Owner 首都儿科研究所
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