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Application of nicotinamide to preparation of drugs for healing diabetic wounds

A technology for wound healing and diabetes, which is applied in the field of medicine, can solve the problems that there are no literature reports on nicotinamide wound healing, and achieve the effect of promoting wound healing, wide therapeutic window and high safety

Inactive Publication Date: 2013-10-09
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] There are no relevant literature reports on the research of nicotinamide on wound healing in diabetes

Method used

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  • Application of nicotinamide to preparation of drugs for healing diabetic wounds
  • Application of nicotinamide to preparation of drugs for healing diabetic wounds
  • Application of nicotinamide to preparation of drugs for healing diabetic wounds

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Example 1: Niacinamide can promote wound healing in diabetic mice

[0023] The incision injury model of diabetic mice was prepared as follows: an 8-week-old diabetic model mouse (db / db mouse, Nanjing Model Animal Center) was anesthetized, and the skin was incised at the left groin to form a 1 cm-long wound. Incision, followed by sutures.

[0024] The administration group was given nicotinamide (purchased from Sigma-Aldrich, 20 mg / kg / day, administered orally).

[0025] The control group was given normal saline.

[0026] After 2 weeks of administration, the healing of the local incision was observed with the naked eye. Healing rate calculation formula: healing rate = healing / (healing + non-healing) × 100%. The results show that nicotinamide can significantly promote wound healing rate (Table 1); detailed pictures can be seen figure 1 , Niacinamide can significantly promote wound healing rate.

[0027] Table 1. Nicotinamide Promotes Wound Healing Rate in Diabetic Mi...

Embodiment 2

[0030] Example 2: Niacinamide promotes the reconstruction of blood circulation in limbs after ischemia in diabetic mice

[0031] The lower limb ischemia model of diabetic mice was prepared as follows: an 8-week-old diabetic model mouse (db / db mouse, Nanjing Model Animal Center) was anesthetized, the skin was incised at the left groin, and the femoral artery, After the femoral vein was blocked with a hemostat, the femoral artery was cut with scissors.

[0032] The administration group was given nicotinamide (purchased from Sigma-Aldrich, 20 mg / kg / day, administered orally).

[0033] The control group was given normal saline.

[0034] After 2 weeks of administration, the laser Doppler blood flowmeter of Perimed Company of the United Kingdom was used to detect the blood circulation reconstruction of the limbs in the ischemic model in real time. The results show that nicotinamide can promote the reconstruction of limb blood circulation after ischemia model (Table 2); detailed pic...

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Abstract

The invention relates to the technical field of drugs and provides an application of nicotinamide to preparation of drugs or health products for healing diabetic wounds. Nicotinamide is a type of vitamin B3. Animal experiments prove that nicotinamide can effectively promote diabetic wound healing, has great significance in treating diabetic gangrene, and has high safety and wide therapeutic window as a drug.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the application of nicotinamide in the preparation of wound healing medicine for treating diabetes. Background technique [0002] The pathogenesis of diabetes is complex, seriously endangers human health, and usually brings serious complications. Difficulty in healing the wounds of diabetic patients is a difficult point in the treatment of diabetes. The main reason is that high blood sugar damages the microcirculatory vessels and causes poor blood circulation in the extremities, especially the lower extremities. The consequence is that the limb wounds will not heal for a long time, leading to gangrene or even amputation, which brings huge physical and mental harm to the patient. This disease is often referred to as "diabetic foot". Therefore, seeking therapeutic drugs that can promote wound healing in diabetes has always been one of the hotspots in the field of diabetes resear...

Claims

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Application Information

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IPC IPC(8): A61K31/455A23L1/29A61P3/10A61P17/02A23L33/00
Inventor 缪朝玉王培赵衍宋捷
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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