Application of babysbreath isoorientin for preparing medicines for treating alcoholic liver injury

A technology of alcoholic liver injury and Gypsophila gypsophila, applied in the field of application in the preparation of drugs for the treatment of alcoholic liver injury

Inactive Publication Date: 2013-09-18
黄权芳 +1
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

[0003] Gypsophila elegans Bieb (Gypsophila elegans Bieb), also known as carnation, Xiacao, etc., is a plant of the genus Stone Flower in the family Caryophyllaceae [1] , is a traditional anti-liver disease herbal medicine in Guangxi Zhuang nationality area, and one of its main active ingredients, isoorientin-2″-O-α-L-arabinopyranosyl (IOA), has little effect on alcohol-induced liver injury. no report

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  • Application of babysbreath isoorientin for preparing medicines for treating alcoholic liver injury

Examples

Experimental program
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Embodiment Construction

[0016] 1. Preparation of Gypsophila isoorientin

[0017] Extraction method: After crushing 10 kg of dried Gypsophila gypsophila, reflux extraction with 80 L of 75% ethanol for 3 times, combine the 3 ethanol extracts, recover ethanol, and obtain 315.7 g of ethanol extract. Add 630ml of distilled water to the ethanol extract and shake well to form a suspension, and then use petroleum ether, ethyl acetate, and n-butanol to extract sequentially. Extract with 630ml of ethyl acetate, discard the ethyl acetate solution; finally, extract with 630ml of n-butanol, recover n-butanol, and obtain 177.6g of n-butanol extract.

[0018] Purification method: Add D101 macroporous resin to n-butanol extract, first elute with 5 times the amount of water, then elute with 10 times the amount of 90% methanol, recover the methanol, and obtain the crude extract. Dissolve the crude extract in methanol, mix the sample with the same amount of silica gel, load the sample on the silica gel column, and use...

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Abstract

The invention discloses an applicative research of an active ingredient of a traditional Chinese medicine babysbreath isoorientin for preparing medicines for treating alcoholic liver injury. First, the babysbreath isoorientin for treating alcoholic liver injury is researched, and animal experiments show that the for the babysbreath isoorientin can be acted on a plurality of links or targets of alcoholic liver injury, and effectively inhibits lipid peroxidation reaction, alleviates pathological injury of liver tissues, inhibits collagen deposition and accelerates apoptosis of hepatic stellate cells, so that the liver injury is remarkably alleviated. The babysbreath isoorientin has unique advantage to prevent and treat liver injury, and is a very potential novel medicine for treating alcoholic liver injury.

Description

technical field [0001] The present invention relates to the use of the extract of the traditional Chinese medicine Gypsophila gypsophila, in particular the application of the gypsophila isoorientin as a raw material in the preparation of drugs for treating alcoholic liver injury. Background technique [0002] Alcoholic liver injury caused by alcoholism is an important pathological process for the development of alcoholic liver disease to cirrhosis, and many studies have confirmed that it can still be reversed. Therefore, effective treatment of alcoholic liver injury is not only a good opportunity to treat alcoholic liver disease, but also to block or The key to delaying the progression of chronic alcoholic liver disease to cirrhosis. At present, there is still no clear plan and effective drug for the clinical treatment of alcoholic liver injury. In recent years, a large number of studies at home and abroad have shown that natural medicines and traditional Chinese medicines ...

Claims

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Application Information

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IPC IPC(8): A61K36/10A61P1/16
Inventor 黄权芳林兴陈永欣黄仁彬张士军吕淑娟韦玲梁春宏
Owner 黄权芳
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