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Suspension granules for cefixime composition and preparation method thereof

A technology of cefixime and suspended granules, which is applied in pharmaceutical formulations, medical preparations with inactive ingredients, and medical preparations containing active ingredients, etc. It can inhibit the growth of streptococcus and the production of acid, which is conducive to safe use and long-term storage, and improves the stability and suspension.

Active Publication Date: 2013-09-18
SHANDONG LUOXIN PARMACEUTICAL GROUP STOCK CO LTD +3
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, too many component selections have also become one of the influencing factors for the low stability of cefixime, which is not conducive to safe clinical use and long-term storage, and its suspension is not high, which needs to be improved

Method used

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  • Suspension granules for cefixime composition and preparation method thereof
  • Suspension granules for cefixime composition and preparation method thereof
  • Suspension granules for cefixime composition and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Embodiment 1: Preparation of cefixime composition suspension granules of the present invention

[0027]

[0028] Pass cefixime and xylitol through a 100-mesh sieve for later use; weigh cefixime, xylitol, xanthan gum and sodium polyacrylate and mix well, use 50% ethanol soft material and 16-mesh sieve to wet granulate , the granules are air-dried at about 50-60°C, the dry granules are sized to 16 mesh, sprayed with apple essence and mixed evenly, the intermediate products are tested, and then packed.

Embodiment 2

[0029] Embodiment 2: Preparation of cefixime composition suspension granules of the present invention

[0030]

[0031] Pass cefixime and xylitol through a 100-mesh sieve for later use; weigh cefixime, xylitol, xanthan gum and sodium polyacrylate and mix well, use 50% ethanol soft material and 16-mesh sieve to wet granulate , the granules are air-dried at about 50-60°C, the dry granules are sized to 16 mesh, sprayed with apple essence and mixed evenly, the intermediate products are tested, and then packed.

Embodiment 3

[0032] Embodiment 3: Preparation of cefixime composition suspension granules of the present invention

[0033]

[0034] Pass cefixime and xylitol through a 100-mesh sieve for later use; weigh cefixime, xylitol, xanthan gum and sodium polyacrylate and mix well, use 50% ethanol soft material and 16-mesh sieve to wet granulate , the granules are air-dried at about 50-60°C, the dry granules are sized to 16 mesh, sprayed with apple essence and mixed evenly, the intermediate products are tested, and then packed.

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Abstract

The invention relates to the field of a pharmaceutical preparation, and particularly discloses suspension granules of a cefixime composition and a preparation method thereof. The suspension granules of the cefixime composition disclosed by the invention include effective components of herbs: cefminox, xylitol, 50% ethanol, xanthan gum, sodium polyacrylate and apple essence; and the weight-average molecular weight of the sodium polyacrylate is 90000-540000. Preferably, the cefminox, the xylitol, 50% of ethanol, the xanthan gum, the sodium polyacrylate and the apple essence are taken as effective compositions of herbs of cefminox suspension granules. Stable performance and suspension property of the cefixime are improved by synergistic effects; the medication compliance of a sufferer is improved; the safety use and long-term storage of a clinical drug are facilitated.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a cefixime composition suspension granule and a preparation method thereof. Background technique [0002] Cefixime (Cefixime) is an oral third-generation cephalosporin antibiotic with the chemical name (6R,7R)-7-[(Z)-2-(2-amino-4-thiazolyl)-2- (Carboxymethoxyimino)acetamido]-8-oxo-3-ethylene-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid trihydrate, structural formula as follows: [0003] [0004] Cefixime has the advantages of broad antibacterial spectrum, high efficiency, wide distribution in the body, good tissue penetration, and stability to β-lactamase. It has antibacterial activity against some Gram-positive bacteria and negative bacteria, especially against Streptococcus (except Enterococcus) among Gram-positive bacteria, pneumococcus, Neisseria gonorrhoeae and Branham's among Gram-negative bacteria Cocci, Escherichia coli, Klebsiella, Serratia, Prot...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K47/10A61K47/32A61K47/36A61K31/546A61P31/04
Inventor 乔凤云牛洪芬李志滨程楚
Owner SHANDONG LUOXIN PARMACEUTICAL GROUP STOCK CO LTD
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