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Preparation method for extracting chlorogenic acid from honeysuckle

A technology of honeysuckle and chlorogenic acid is applied in the separation/purification of carboxylic acid esters, organic chemistry and other directions, which can solve the problems of high extraction temperature, complicated steps and low chlorogenic acid content, and achieves low extraction temperature, simple process, high content

Inactive Publication Date: 2013-09-11
孙玉平
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The process steps in the prior art are complicated, and the extraction temperature is high, resulting in the destruction of the active ingredients, and the content of chlorogenic acid in the extracted product is low, and the curative effect needs to be improved

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] A kind of preparation method of extracting chlorogenic acid from honeysuckle of the present invention comprises the following steps:

[0016] a: Prepare the original medicinal material honeysuckle, wash, dry, the drying temperature is 50°C, the drying time is 2 hours, and pulverize to 10 meshes to obtain honeysuckle powder;

[0017] b: extract the honeysuckle powder obtained in step a in water twice, each time for 3 hours, the mass ratio of honeysuckle powder and water is 1:10, and combine the extracts;

[0018] c: adjusting the pH value of the extract obtained in step b to 2, then adsorbing it with a macroporous resin, and then eluting with 70% ethanol and 50% ethanol respectively, and combining the eluents to obtain a crude extract;

[0019] d: adjusting the pH value of the crude extract obtained in step c to 2, then extracting, separating, concentrating, and drying to obtain the finished chlorogenic acid.

[0020] The method of the invention has the advantages of si...

Embodiment 2

[0022] A kind of preparation method of extracting chlorogenic acid from honeysuckle of the present invention comprises the following steps:

[0023] a: Prepare the original medicinal material honeysuckle, wash, dry, the drying temperature is 55°C, the drying time is 1.5h, and pulverize to 20 mesh to obtain honeysuckle powder;

[0024] b: Extract the honeysuckle powder obtained in step a in water for 3 times, each time for 2 hours, the mass ratio of honeysuckle powder and water is 1:15, and combine the extracts;

[0025] c: adjusting the pH value of the extract obtained in step b to 4, then adsorbing it with a macroporous resin, and then eluting with 75% ethanol and 55% ethanol respectively, and combining the eluents to obtain a crude extract;

[0026] d: adjusting the pH value of the crude extract obtained in step c to 4, then extracting, separating, concentrating, and drying to obtain the finished chlorogenic acid.

[0027] The method of the invention has the advantages of s...

Embodiment 3

[0029] A kind of preparation method of extracting chlorogenic acid from honeysuckle of the present invention comprises the following steps:

[0030] a: Prepare the original medicinal material honeysuckle, wash, dry, the drying temperature is 60°C, the drying time is 1 hour, and pulverize to 30 mesh to obtain honeysuckle powder;

[0031] b: extract the honeysuckle powder obtained in step a in water for 5 times, each time for 1 hour, the mass ratio of honeysuckle powder and water is 1: 20, and combine the extracts;

[0032] c: adjusting the pH value of the extract obtained in step b to 6, then adsorbing it with a macroporous resin, and then eluting with 80% ethanol and 60% ethanol respectively, and combining the eluents to obtain a crude extract;

[0033] d: adjust the pH value of the crude extract obtained in step c to 6, then extract, separate, concentrate, and dry to obtain the finished chlorogenic acid.

[0034] The method of the invention has the advantages of simple proce...

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Abstract

The invention discloses a preparation method for extracting chlorogenic acid from honeysuckle. The preparation method is characterized by comprising the following steps of: a, preparing a raw medicinal material, namely the honeysuckle, cleaning and drying the honeysuckle, and smashing the honeysuckle into honeysuckle powder of 10-30 meshes; b, extracting the honeysuckle powder obtained in the step a for 2-5 times with each extraction time for 1-3 hours, and combining the extracts; c, adjusting the pH value of the extract obtained in the step b to 2-6, then adsorbing the extract by macroporous resin, diluting the extract by ethanol of 70-80 percent and 50-60 percent, and combining diluted liquids to obtain a rough extracted object; and d, adjusting the pH value of the rough extracted object obtained in the step c, then extracting, separating, concentrating and drying the rough extracted object to obtain the finished product chlorogenic acid. The preparation method has the advantages that the technology is simple, the extraction temperature is low, effective components cannot be damaged, the extracted chlorogenic acid content is high, and the treating effect is better.

Description

technical field [0001] The invention relates to an extract from honeysuckle, in particular to a preparation method for extracting chlorogenic acid from honeysuckle. Background technique [0002] Honeysuckle is the dry flower bud or the flower with the first bloom of Lonicera Lonicera, Lonicera red glandularis, and mountain silver flower. Honeysuckle is a commonly used traditional Chinese medicine. It is cold in nature and sweet in taste. It has significant heat-clearing and detoxifying, anti-bacterial, anti-inflammatory and anti-viral effects. fever. One of the main active ingredients is chlorogenic acid, which is considered to be the main active ingredient of many medicinal materials and Chinese patent medicines for antibacterial, detoxifying, anti-inflammatory and choleretic, and is usually used as a qualitative or even quantitative indicator. The process steps in the prior art are complicated, and the extraction temperature is high, resulting in the destruction of the a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C69/732C07C67/48
Inventor 孙玉平
Owner 孙玉平
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