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Pharmaceutical composition for improving climacteric symptoms and preparation method of pharmaceutical composition

A technology of composition and medicine, which is applied in the field of pharmaceutical composition and its preparation, can solve the problems of soy isoflavones, such as restrictions on the applicable population and rare products, and achieve the effects of improving trace element deficiency, eating convenience, and improving health care functions

Active Publication Date: 2013-08-21
BEIJING ZHONGYAN TONGRENTANG CHINESE MEDICINE R & D
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the raw materials of similar products on the market are mostly soybean isoflavones and calcium supplements, but soybean isoflavones have some restrictions on the applicable population, and there are few products that use pure Chinese herbal medicine compound according to the theory of Chinese medicine

Method used

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  • Pharmaceutical composition for improving climacteric symptoms and preparation method of pharmaceutical composition
  • Pharmaceutical composition for improving climacteric symptoms and preparation method of pharmaceutical composition
  • Pharmaceutical composition for improving climacteric symptoms and preparation method of pharmaceutical composition

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0032] Experimental Example 1. Investigation on the extraction process of Ligustrum lucidum, Eclipta chinensis, and Cyperus alcohol

[0033] 1. Optimal extraction process parameters screening test

[0034] Ligustrum lucidum, Eclipta chinensis, and Cyperus cyperus are all commonly used traditional Chinese medicines, among which the active ingredients of Ligustrum lucidum are triterpenoids, the active ingredients of Eclipta edulis are wedelia lactone and other components, and the active ingredients of Cyperus cyperi are saponins, flavonoids kind. This product uses wedelolactone as the symbolic ingredient, and it can be extracted with ethanol to achieve better results.

[0035] Because alcohol extraction has simple and popular equipment, low cost, low production site requirements, easy operation, and is suitable for large-scale industrial production; at the same time, the alcohol extraction method generally adopts the heat reflux method in industry, which can retain active ingre...

experiment example 2、 100

[0050] Experimental example 2, research on the water extraction process of lily, oyster, wild jujube seed and Anemarrhena

[0051] Lily, oyster, jujube seed, and Anemarrhena are all commonly used traditional Chinese medicines, mainly composed of saponins and polysaccharides, and better results can be obtained by water extraction.

[0052] Because water extraction has simple and popular equipment, low cost, low production site requirements, easy operation, and is suitable for large-scale industrial production; at the same time, water extraction method generally adopts thermal reflux method in industry, which can retain active ingredients and achieve the purpose of removing roughness and extracting essence. The main components of the lily, oyster, wild jujube seed, and anemarrhena in this prescription are mainly water-soluble substances, which can improve sleep, so water is used as a solvent for extraction. By selecting L9(3 4 ) orthogonal table, design a three-factor three-lev...

experiment example 3

[0061] Experimental Example 3: Concentration, drying, and pulverization of alcohol-extracted extracts and water-extracted extracts

[0062] After laboratory research, we have formulated the process concentration conditions and the degree of concentration. The temperature is 70°C and the pressure is 0.08Mpa. Concentrate under reduced pressure, and concentrate to a thick extract with a relative density of 1.15-1.25 (50°C heat test); dry using The vacuum drying method is carried out, and the drying parameters are as follows: temperature is 60°C, vacuum degree is 0.08Mpa, and the time is 50-60 hours; crushed and sieved, and sieved with an 80-mesh sieve. This process has been scaled up by the pilot test to correct the deviation and determine the scientific and reasonable process technical parameters.

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Abstract

The invention discloses a pharmaceutical composition for improving climacteric symptoms. The pharmaceutical composition comprises the following materials in parts by weight: 12-20 parts of glossy privet fruits, 12-20 parts of eclipta, 8-15 parts of rhizoma cyperi, 4-10 parts of lilies, 14-25 parts of oysters, 12-20 parts of spina date seeds, 4-14 parts of rhizoma anemarrhenae and 0.1-2.5 parts of oviductus ranae. The preparation method of the pharmaceutical composition comprises the following steps of: extracting and concentrating the glossy privet fruits, the eclipta and the rhizoma cyperi by alcohol to obtain thick extract A; water-extracting and concentrating the lilies, the oysters and the rhizoma anemarrhenae to obtain thick extract B; mixing the thick extract A with the thick extract B, drying, crushing and sieving to dry extract powder; crushing and sieving the oviductus ranae; and mixing the dry extract powder with the oviductus ranae, adding normal auxiliary materials for preparing an oral solid preparation according to a normal process. The pharmaceutical composition disclosed by the invention has the function of improving the climacteric symptoms, and can be used for preparing healthcare food, common food or drugs.

Description

technical field [0001] The invention relates to a pharmaceutical composition and a preparation method thereof, in particular to a pharmaceutical composition capable of improving menopausal symptoms and a preparation method thereof. Background technique [0002] For women, menopause refers to a transitional period in which women's ovarian function gradually declines from a vigorous state to complete disappearance, including menopause and the period before and after menopause. Traditional Chinese medicine calls it "perimenopause syndrome". During menopause, women may experience a series of physical and psychological changes, called menopausal syndrome, specifically manifested in a series of symptoms caused by perimenopausal endocrine disorders such as anxiety, hot flashes, insomnia, and osteoporosis. , it is the result and early manifestation of the overall aging of women. Due to the great physiological and psychological changes of women during menopause, they will be trouble...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8967A23L1/29A61P15/12A61K35/56A23L33/00A61K35/618A61K35/65
Inventor 周天浩解素花徐京李晋生吴炜刘名徐意
Owner BEIJING ZHONGYAN TONGRENTANG CHINESE MEDICINE R & D
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