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Contrast medium composition with contrast enhancement effect by comprising highly concentrated agent

A technology of contrast agent and composition, which is applied in X-ray contrast agent preparation, drug delivery, preparations for in vivo tests, etc., can solve the problems that cannot meet the needs of more accurate and more accurate diagnosis of image diagnosis, and achieve excellent clarity and discriminative effect

Inactive Publication Date: 2013-06-26
CENT MEDICAL SERVICE CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0022] However, due to the rapidly increasing demand and expectation (early diagnosis and precise diagnosis) in the medical market for the development of medical technology and diagnosis, previously approved contrast agent compositions cannot meet the requirements of image diagnosis for more precise and accurate diagnosis

Method used

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  • Contrast medium composition with contrast enhancement effect by comprising highly concentrated agent
  • Contrast medium composition with contrast enhancement effect by comprising highly concentrated agent
  • Contrast medium composition with contrast enhancement effect by comprising highly concentrated agent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] Embodiment 1:380mgI / ml iohexol injection preparation

[0059] To obtain a concentration of iohexol in the contrast medium composition of 380 mgI / ml, 819.71 g of iohexol, 1.31 g of tromethamine, and 0.11 g of calcium disodium edetate were completely dissolved by stirring at room temperature (RT) In 75ml water for injection (WFI). The pH was controlled to 7.79 with 1N hydrochloric acid solution, and water for injection was added to make the final volume of the preparation 1 L. The resulting solution was then sterile filtered using a microfilter. The resulting solution was poured into a 100 mL vial, and then the vial was sealed with a rubber stopper and an aluminum cap to obtain an injection preparation.

Embodiment 2

[0060] Embodiment 2:360mgI / ml iohexol injection preparation

[0061] An injection preparation was obtained in a similar manner to Example 1 except that 776.62 g of iohexol and 1.24 g of tromethamine were used to make the iohexol concentration 360 mgI / ml.

Embodiment 3

[0062] Embodiment 3:400mgI / ml iohexol injection preparation

[0063] An injection preparation was obtained in a similar manner to Example 1 except that 862.80 g of iohexol and 1.38 g of tromethamine were used to make the iohexol concentration 400 mgI / ml.

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Abstract

The present invention relates to a contrast medium composition (formulation) comprising a highly concentrated contrast agent for use in an imaging method. The contrast medium composition comprises an aqueous contrast agent selected from the group consisting of iopentol, iotrolan, iohexol, ioversol, ioxilan, iodixanol and iobitridol in an amount of 360 mgl / mL to 450 mgI / mL. The contrast medium composition according to the present invention, which comprises iodine working as a contrast agent in a higher concentration than the concentration used before, shows higher contrast enhancement effect in both of arterial phase and portal phase when used for liver CT than a composition comprising the contrast medium in a concentration used before. Accordingly, images having excellent resolution and discrimination can be obtained.

Description

technical field [0001] The present invention relates to contrast agent compositions for use in imaging methods, and more particularly to contrast agent compositions comprising a high concentration of contrast agent thereby having a high contrast enhancing effect. Background technique [0002] CT (Computed Tomography) is an imaging method in which X-rays are emitted from various directions to a desired part of the human body, the transmitted X-rays are collected by a detector, and the difference in X-ray absorption at that part is calculated by a computer, followed by These data are reconstructed through mathematical techniques. The basic principle of CT is as follows: X-ray beams are emitted while an X-ray tube is rotated around a section of a body part, and intensity data is collected by a detector, which is then used in part by a computer to calculate absorption intensities and reconstruct an image from the calculated data, followed by Display it on the monitor. [0003]...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/04
CPCA61K49/0438A61K49/0452
Inventor 金富根金英一
Owner CENT MEDICAL SERVICE CO LTD
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