Composition and activity evaluation of a traditional Chinese medicine compound with broad-spectrum antibacterial activity

A technology of traditional Chinese medicine and compound preparations, which is applied in the direction of antibacterial drugs, antifungal agents, and pharmaceutical formulas, and can solve the problems of pure Chinese medicine preparations with broad-spectrum antibacterial activity that have not been found yet.

Inactive Publication Date: 2015-11-25
YANBIAN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, the liquid spray formulations that have been published or commercially used are mostly chemical preparations or chemical preparations and Chinese medicine liquid mixtures used in antibacterial skin care preparations, and no pure Chinese medicine preparations with broad-spectrum antibacterial activity have been found.

Method used

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  • Composition and activity evaluation of a traditional Chinese medicine compound with broad-spectrum antibacterial activity
  • Composition and activity evaluation of a traditional Chinese medicine compound with broad-spectrum antibacterial activity

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0017] 1. The preparation process of traditional Chinese medicine compound is as follows

[0018] (1) Extraction process of St. John's Wort:

[0019] Supercritical extraction process: Take 1.2kg of dried and crushed St. John's Wort and put it into the extraction kettle. The extraction pressure is 25MPa, the temperature is 45°C, and the CO 2 Under the condition of a flow rate of 143.5kg / L, the extract was extracted for 2 hours to obtain 12g of Hypericum lanceolata extract, with a yield of 1%.

[0020] (2) Take 100g of dried pomelo, add appropriate amount of 95% ethanol, reflux and extract at 80°C for 2 hours, then filter, add the same amount of ethanol to the dregs, reflux and extract for 1 hour, then filter, combine the two extracts, and concentrate to obtain the extract 26.2 g, yield 26.2%.

[0021] (3) Take cassia bark 100g, add appropriate amount of 95% ethanol and filter under reflux for 2 hours at 80°C, add the same amount of ethanol to the medicinal material, filter af...

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Abstract

The invention relates to a traditional Chinese medicine compound composition having a broad-spectrum antimicrobial activity and activity evaluation thereof, and belongs to the technical field of medicine. Through a supercritical extraction method and an ethanol reflux extraction method, crude extract is extracted from hypericum ascyron, cassia bark and shaddock. The traditional Chinese medicine compound composition is convenient for operation, has short onset time, is not precipitated, has a long preservation period, and goes bad difficultly. The traditional Chinese medicine compound composition has a broad-spectrum antimicrobial activity and good effects of resisting 27 common bacteria comprising methicillin-resistant staphylococcus aureus and quinolone-resistant staphylococcus aureus, and can be used as a raw material of a natural antibacterial agent and a preservative.

Description

[0001] Field: [0002] The invention relates to a traditional Chinese medicine compound, in particular to the preparation and activity evaluation of a natural plant compound spray with broad-spectrum antibacterial effect. Background technique: [0003] Chinese medicine companies in my country have benefited a lot from the social action of "restricting the sale" of western medicine antibiotics. The output and sales volume of Chinese medicine production enterprises have increased several times, and the concentration of the Chinese medicine industry has been improved. Yuandan, Jizhi Syrup, Toad Needle, Tongluo Shenggu Capsule and other traditional Chinese medicine words have been integrated into people's health care life at once. However, after the "restricted sales hurricane", it will not only bring business opportunities to Chinese medicine companies, but also will be a test of my country's traditional Chinese medicine product innovation capabilities. In the past two years, the...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/752A61P31/04A61P31/10
CPCY02A50/30
Inventor 郑昌吉常月李因晶刘一
Owner YANBIAN UNIV
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