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Colloidal bismuth pectin capsule

A technology of colloidal bismuth pectin and capsules, which can be used in capsule delivery, medical preparations of non-active ingredients, digestive system, etc., and can solve problems such as affecting drug effects, forming colloids, and slow decomposition speed

Active Publication Date: 2013-06-12
CP PHARMA QINGDAO CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Currently commercially available colloidal bismuth pectin capsules decompose slowly in gastric acid, and cannot quickly form sol in the stomach after oral administration, which affects the drug effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Add 300g of colloidal pectin bismuth (calculated as bismuth, converted into pure), 9g of micronized silica gel, and pregelatinized starch (990g) with auxiliary materials and excipients to a total weight of 3800g. Make 1000 pieces.

[0019] Preparation:

[0020] Take 300g of colloidal pectin bismuth (calculated as bismuth, converted into pure), 9g of micronized silica gel, and pregelatinized starch (990g), mix well, and wet granulate. Sieving, drying, and filling into capsule shells to make hard capsules, each capsule is about 0.4g.

Embodiment 2

[0022] Add 200 g of colloidal pectin bismuth (calculated as bismuth, converted to pure), 5 g of micronized silica gel, and pregelatinized starch (1000 g) with auxiliary materials and excipients to a total weight of 3800 g. Make 1000 pieces.

[0023] The preparation method is the same as above.

Embodiment 3

[0025] Add 400g of colloidal pectin bismuth (calculated as bismuth, converted into pure), 10g of micronized silica gel, and pregelatinized starch (1100g) with auxiliary materials and excipients to a total weight of 3800g. Make 1000 pieces.

[0026] The preparation method is the same as above.

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PUM

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Abstract

The invention provides a colloidal bismuth pectin capsule. In the colloidal bismuth pectin capsule, aerosil and pregelatinized starch are mixed with colloidal bismth pectin in a specific proportion.

Description

Technical field [0001] The invention relates to a colloidal pectin bismuth capsule. Background technique [0002] At present, there are many kinds of drugs for treating gastric ulcer on the market, such as Livzon Dele, Sanjiu Weitai, etc., but they are expensive and the treatment effect is not satisfactory. These drugs can only relieve symptoms, and over time, the old disease will relapse and even cause other diseases. [0003] Colloidal pectin bismuth is a compound of indeterminate composition formed by pectin and bismuth. The pectin-containing bismuth is calculated as bismuth (Bi) and should be 14.0% to 16.0%. Colloidal pectin bismuth is a new type of macromolecular bismuth agent with large molecular weight, stable colloid, difficult to be absorbed by the human body, and no adverse reactions and side effects easily caused by similar drugs. Mainly used to treat chronic gastritis. Colloidal bismuth pectin replaces the medium and small molecular acid radicals in traditional bism...

Claims

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Application Information

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IPC IPC(8): A61K9/48A61K31/732A61K47/36A61K47/04A61P1/04
Inventor 王明刚任莉陈阳生
Owner CP PHARMA QINGDAO CO LTD
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