Application of N-acetylglucosamine isomerase in production of N-acetylmannosamine
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A technology of acetylglucosamine and acetylmannosamine, which is applied in the field of the invention, can solve the problems of no PmAGE and other problems, and achieve the effect of reducing production costs
Active Publication Date: 2014-06-04
NANJING TECH UNIV
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So far, no report of PmAGE being used for ManNAc synthesis has been found
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Abstract
The invention discloses application of N-acetylglucosamine isomerase of which the amino acid sequence is shown as SEQ ID NO:2 in catalytic synthesis of N-acetylmannosamine. The N-acetylmannosamine is prepared by taking the N-acetylglucosamine isomerase of which the amino acid sequence is shown as SEQ ID NO:2 as a catalyst and taking N-acetylglucosamine as a substrate. According to the invention, the N-acetylglucosamine isomerase of which the amino acid sequence is shown as SEQ ID NO:2 is used in the preparation of the N-acetylmannosamine for the first time, and favorable effect is achieved.
Description
technical field [0001] The invention belongs to the field of biotechnology, and relates to an application of N-acetylglucosamine isomerase (N-acetylglucosamine 2-epimerase, AGE), in particular to a kind of N-acetylglucosamine isomerase from seaweed Prochlorococcus marinus str.MIT9215. Application of PmAGE in the production of N-acetyl-D-mannosamine (ManNAc) with N-acetyl-D-glucosamine (GlcNAc) as substrate. Background technique [0002] N-acetyl-mannosamine (N-acetyl-D-mannosamine, ManNAc) is an important intermediate, which can be used as anti-influenza drug precursor and infant milk powder additive N-acetylneuraminic acid (N-acetyl-D- neuraminic acid, Neu5Ac) synthesis. [0003] Using N-acetyl-D-glucosamine (GlcNAc) as a substrate for the synthesis of ManNAc, and then using ManNAc and pyruvate as substrates through N-acetylneuraminic acid lyase (N-acetylneuraminic acid lyase, Nal) catalyzed synthesis of N-acetylneuraminic acid is currently the most important way to synth...
Claims
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Application Information
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