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Topical treatments for pain

A topical composition, technology of inhibitors, applied in the field of its delivery, can solve the problem of non-prescription treatment for the pain of improving tissue oxygenation

Inactive Publication Date: 2013-04-24
MCGILL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In addition, there are no prescribed treatments for pain that target increased tissue oxygenation, which can be used to treat neuropathic, inflammatory, ischemic, or muscular pain

Method used

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  • Topical treatments for pain
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Experimental program
Comparison scheme
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other Embodiment approach

[0064] Other embodiments include methods for treating a subject suffering from neuropathic pain comprising topically administering an effective amount of a composition comprising a therapeutically effective amount of PA formulated in a pharmaceutically acceptable carrier for topical treatment or PDE inhibitors combined with α2-adrenergic agonists or nitric oxide donors. In an embodiment, the neuropathic pain is peripheral neuropathic pain.

[0065] It is to be understood that, in addition to preventing or treating pain, combinations of agents of the invention and compositions thereof can increase tissue oxygenation; increase thermoregulatory and / or nutritional blood flow; have antioxidant , anti-cytokine, immunosuppressant and / or mitochondrial protective effects; reduces arterial vasospasm and / or capillary no-reflow; and / or has anti-hyperalgesic effects.

[0066] As used herein, "subject" includes mammals, including humans.

[0067] In an embodiment, the methods disclosed he...

Embodiment

[0092] The present invention will be understood more readily by reference to the following examples, which are provided to illustrate the invention and should not be construed as limiting its scope in any way.

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Abstract

The present invention relates to novel compositions and therapeutic methods for the treatment of pain, in particular neuropathic, ischemic, muscle, arthritic or multiple sclerosis pain. The compositions include a combination of an alpha2-adrenergic agonist or a nitric oxide donor combined with a phosphodiesterase (PDE) or a phosphatidic acid (PA) inhibitor, which have been found to act together synergistically to provide effective treatment for pain, especially when administered topically.

Description

technical field [0001] The present invention relates to novel pharmaceutical compositions and methods for the treatment of neuropathic pain, ischemic pain, and muscular pain. In particular, the present invention relates to topical compositions comprising combinations of ingredients which provide surprising pain relief, and to methods for their administration. Background technique [0002] Complex Regional Pain Syndrome (CRPS) is a chronic progressive disorder characterized by severe pain, swelling and skin changes. CRPS patients are divided into two subcategories: CRPS-I without major nerve damage and CRPS-II with major nerve damage. Tissue damage in patients with CRPS leads to the production of anaerobic free radicals and pro-inflammatory cytokines (pro-inflammatory cytokines), which cause microvascular damage, including capillary no-reflow, arteriovenous shunting, and lower capillary filtration capacity (Matsumura et al. , Scand J Plast Reconstr Surg Hand Surg 1996; 30:1...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/5377A61K31/4168A61K31/522A61P29/00
CPCA61K31/198A61K31/522A61K31/5377A61K31/4168A61K45/06A61P25/00A61P29/00A61K2300/00
Inventor 特伦斯·科德尔里安德烈·拉费里埃瓦伊甘达·拉加温德兰·热加德埃萨恩
Owner MCGILL UNIV
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