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Method for fast constructing and repairing skin defects by tissue engineering skins

A technology for tissue engineering skin and repairing skin, which is applied in the medical field, can solve the problems of long product cycle and inability to overcome the survival rate of skin grafts, and achieve the effects of increasing survival rate, improving skin color and texture, and promoting wound healing

Inactive Publication Date: 2013-04-24
朱家源
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Although the new methods have improved and promoted the treatment level of wound repair to a certain extent, they also have their own shortcomings, and cannot overcome the shortcomings of low survival rate of skin grafts and long product cycle.

Method used

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Embodiment Construction

[0008] The present inventors have accumulated rich experience in the application of composite skin transplantation of allogeneic acellular dermis and autologous thin skin sheets when repairing body surface defects, and achieved good clinical effects. But at the same time, there are also problems that the survival rate fails to meet the ideal requirements, and the skin texture, color and skin function after survival still have a gap with normal skin. Recently, the inventors have applied a method of rapidly obtaining skin basal cell suspension to clinical practice. The cell suspension has good effects in promoting wound healing, improving the survival rate of skin grafts, and improving the color and texture of the skin after healing. After preliminary research, the cell suspension contains basal cells, Langerhans cells, melanocytes, fibroblasts and epidermal stem cells. The rich active cell population is the reason for its clinical effect. Epidermal stem cells are currently one ...

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Abstract

The invention discloses a method for fast constructing and repairing skin defects by tissue engineering skins and belongs to the field of medical methods. The method can be used for solving the defects of low survival rate of skin grafts and long period of the traditional medical method, wherein the method is formed by a razor-thin graft and a cell suspension in combination with a composite skin grafting method. The method for fast constructing and repairing the skin defects by the tissue engineering skins has good effects of promoting wound healing, enhancing the survival rate of the razor-thin graft, and improving the color and texture of skins, and can effectively treat skin defects resulted from various reasons such as a trauma and a surgery.

Description

technical field [0001] The invention relates to the field of medical methods, in particular to a method for rapid tissue engineering skin construction and repair of skin defects. Background technique [0002] Large-area skin defects caused by various reasons, such as burns and traumas, are the main problems faced by burn surgery and plastic surgery. In order to effectively solve the problem of skin source and repair effect, new technologies and methods are constantly emerging. Skin grafts, skin flaps, stamp skin grafts, micro-skin grafts, mesh skin grafts, composite skin grafts, etc. The research on tissue-engineered skin is also continuously deepening. The current tissue-engineered skin includes autologous or allogeneic epidermal sheet dermal substitutes and skin substitutes with a double-layer structure of epidermis and dermis, and the best substitute is still autologous epidermis. Dermal substitutes, because most of the rest are only effective in patients with chronic u...

Claims

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Application Information

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IPC IPC(8): A61B17/322
CPCA61K35/36A61L27/60
Inventor 朱家源
Owner 朱家源
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