Application of Houttuynoid D in preparation of monoamine oxidase (MAO) inhibitor
A technology for monoamine oxidase and inhibitors, applied in the field of preparation of monoamine oxidase (MAO) inhibitors, which can solve the problems of limited application and achieve the effect of strong inhibitory activity and outstanding substantive characteristics
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Embodiment 1
[0013] Embodiment 1: the preparation of compound Houttuynoid D tablet involved in the present invention:
[0014] Take 20 grams of compound Houttuynoid D, add 180 grams of conventional excipients for tablet preparation, mix well, and make 1000 tablets with a conventional tablet press machine.
Embodiment 2
[0015] Embodiment 2: the preparation of the compound Houttuynoid D capsule involved in the present invention:
[0016] Take 20 grams of compound Houttuynoid D, add conventional auxiliary materials for preparing capsules such as 180 grams of starch, mix well, and pack into capsules to make 1000 tablets.
[0017] The following pharmacodynamic experiments will further illustrate its drug activity.
[0018] Compound Houttuynoid D detects the inhibitory activity to MAO-A and MAO-B with the method of fluorescent probe, and described method is carried out according to the following steps:
[0019] Dissolve the sample to be tested in DMSO to prepare a series of samples with concentration gradient. Take 4ul of MAO (10mg / ml), boric acid buffer (PH=8.4), 50ul of BSA (50mg / ml), add the sample solution to be tested, mix well, react in a water bath at 30~38°C for 3h, and then add probe 7 -(3-Aminopropoxy)coumarin 2ul (50mmol / ml), final inhibitor concentration 0~10 -2 mmol / l, the mixture ...
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