Origanum oil oral emulsion and preparation method thereof
An emulsifier and co-emulsifier technology, which is used in pharmaceutical formulations, emulsion delivery, and medical preparations containing active ingredients, etc., can solve the problems of inconvenient mixing, inconvenience for poultry drinking water, and application restrictions of oregano oil.
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[0027] In the preparation method of oregano oil oral milk of the present invention, the preservative is dissolved in an appropriate amount of purified water or low-carbon fatty alcohol, and then dissolved in purified water together with an emulsifier and an emulsifier to form solution A; solution A is added to a colloid mill , adjust the rotation speed, stir and mix for 5-10 minutes; dissolve the antioxidant in the co-emulsifier, and then add it to the oregano oil to become solution B; slowly add solution B to solution A in the colloid mill, and emulsify for 10-60 minutes; Then filter and pack to obtain oregano oil oral milk.
[0028] In the present invention, solution B can be added to the colloid mill first, and then solution A can be added to solution B to emulsify in the colloid mill. The emulsification is accomplished through a tissue masher, milk homogenizer or high pressure shearing machine.
[0029] In the preparation method of oregano oil oral milk of the present inv...
Embodiment 1
[0033] Oregano oil 0.5%, emulsifier 0.5%, co-emulsifier 0.5%, preservative 0.01%, antioxidant 0.005%, purified water 98%; described emulsifier is Tween 80, and described co-emulsifier is propylene glycol, so The preservative is sodium benzoate, and the antioxidant is BHA.
[0034] Dissolve the preservative in an appropriate amount of purified water or low-carbon fatty alcohol, and then dissolve it in purified water together with emulsifier and co-emulsifier to form solution A;
[0035] Dissolve the antioxidant in the co-emulsifier, and then add it to the oregano oil to become solution B;
[0036] Add solution A to the colloid mill, adjust the rotation speed, and stir and mix for 5-10 minutes;
[0037] Slowly add solution B to solution A in the colloid mill, emulsify for 10-60 minutes; then filter and pack separately to obtain oregano oil oral milk.
Embodiment 2
[0039] Oregano oil 5%, emulsifier 15%, co-emulsifier 2%, preservative 0.1%, antioxidant 0.2%, purified water 78%; described emulsifier is Tween 80, and described co-emulsifier is dehydrated alcohol , the preservative is ethylparaben, and the antioxidant is BHA.
[0040] Dissolve the preservative in an appropriate amount of purified water or low-carbon fatty alcohol, and then dissolve it in purified water together with emulsifier and co-emulsifier to form solution A;
[0041]Dissolve the antioxidant in the co-emulsifier, and then add it to the oregano oil to become solution B;
[0042] Add solution B to the colloid mill, adjust the speed, and stir for 5-10 minutes;
[0043] Slowly add solution A to solution B in the colloid mill, emulsify for 10-60 minutes; then filter and pack separately to obtain oregano oil oral milk.
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