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Celecoxib composition, and preparation method and use thereof

A technology of celecoxib and composition, which is applied in the field of celecoxib composition, preparation and use, and can solve the problems of increased tablet hardness and the like

Inactive Publication Date: 2013-03-06
TIANJIN INSTITUTE OF PHARMA RESEARCH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] (5), the hardness of tablet increases;

Method used

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  • Celecoxib composition, and preparation method and use thereof
  • Celecoxib composition, and preparation method and use thereof
  • Celecoxib composition, and preparation method and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0072] Capsules are prepared with the following composition:

[0073]

[0074]

Embodiment 2

[0076] Capsules are prepared with the following composition:

[0077]

Embodiment 3

[0079] Capsules are prepared with the following composition:

[0080]

[0081]

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Abstract

The invention provides a celecoxib composition. The celecoxib composition contains one or more types of dose units which can be orally released, and each of the dose units contains 50-500mg of celecoxib D95 particles and one or more types of mixtures of pharmaceutical excipients. The composition can be used for treating or preventing diseases caused by COX-2.

Description

technical field [0001] The present invention relates to an orally releasable pharmaceutical composition containing active ingredient celecoxib (celecoxib, trade name Celebrex), a method for preparing the composition, and a method for treating cyclooxygenase-2 (COX-2)-induced A method for diseases, said method comprising orally administering said composition to a patient, and the use of said composition in the manufacture of a medicament. Background technique [0002] In 1994, G.D Searle Company of the United States applied for a patent in China, the patent number was CN1141630, and the compound 4-[5-(4-methylphenyl-3-(trifluoromethyl-1H-pyrazole-1) was once reported in the patent -yl] benzenesulfonamide (celecoxib), this patent describes and claims a class of 1,5-diarylpyrazoles and salts thereof and the method for preparing said compound. Celecoxib has the following structure: [0003] [0004] It is reported in CN1141630 that the compound can be used to treat inflammat...

Claims

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Application Information

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IPC IPC(8): A61K31/635A61P19/04A61P29/00A61P19/02A61P9/00A61P9/10
Inventor 梅林雨罗振福梁忠信郑志超高晶靳朝东张晓东
Owner TIANJIN INSTITUTE OF PHARMA RESEARCH
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