Externally-applied skin-generating oil for treatment of burn and preparation method and application thereof

Abstract

The invention relates to the technical field of a traditional Chinese medicine preparation, and particularly discloses externally-applied skin-generating oil for treatment of burns and a preparation method and application thereof. The skin-generating oil is prepared by soaking the following 15 Chinese herbs in sesame oil: radix scutellariae, rheum officinale, astragalus mongholicus, coptis chinensis, cortex phellodendri, angelica sinensis, sanguisorba officinalis, lithospermum, rehmannia, radix angelicae, cynanchum atratum, bletilla striata, olibanum, myrrh and borneol. When the skin-generating oil is applied in treatment of burns, wound infection caused after injury can be prevented effectively, proliferation and migration of fibroblasts and vascular endothelial cells can be promoted, neovascularization can be induced, wound healing can be accelerated, scar repair can be promoted, the wound healing time can be shortened, Class I-II burns can be cured in 10-12 days, and Class III burns of rabbits can be cured in 20-25 days. When Class III burns of rabbits are treated with the skin-generating oil, the wound area can be reduced from 6 cm<2> to 0.1cm<2>, the wound surface is flat, smooth and soft, and newborn hair is normal. The wound epidermis can be recovered completely, dense hair follicles can be formed in the dermis layer, and almost no difference from normal skin tissues can be produced.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine preparations, in particular to an external skin-skin oil for treating burns and scalds, a preparation method and application thereof. Background technique [0002] According to statistics, the annual incidence of burns and scalds in my country accounts for about 0.5% to 1.0% of the total population. Burns and scalds are physical injuries mainly caused by high fever or burning. According to the degree of burns and scalds, burns and scalds can generally be divided into I degree, shallow II degree, deep II degree and III degree burn. Among them, first-degree and second-degree burns are relatively easy to control and treat clinically, while third-degree burns are full-thickness skin injuries, and some even damage subcutaneous tissue, muscles and bones, etc., and the wound is prone to infection and healing after injury. Afterwards, cicatrix of varying degrees are often formed, and...

AI Technical Summary

Problems solved by technology

[0003] At present, western medicine ointment and other dosage forms are mostly used in clinical treatment of I-II degree burns and scalds, but this treatment method has certain side effects, and some wounds have problems of incomplete treatment that leads to recurrence and recurrence (Chinese patent application 201010516285.6 ); at the same time, clinically, skin grafting is often used in the treatment of third-degree burns, but the cost is high and the treatment time is long

At present, there are relatively few traditional Chinese medicine preparations on the market that can effectively treat third-degree burns and scalds. Most of the medicines cannot clear the fire and detoxify in time after use, relieve pain and reduce swelling, and scars are likely to be left after the wound is healed.

Scutellaria baicalensis, rhubarb, astragalus, phellodendron, berberine, burnet, rehmannia glutinosa, Angelica dahurica, Baiwei, bletilla striata, angelica, comfrey, frankincense, myrrh, borneol and other traditional Chinese medicines are commonly used to treat burns and scalds. Mostly used to treat I and II degree burns, rarely used for treatment of III degree burns (Encyclopedia of Chinese Burns. Beijing: Academy Press. 1998: 234-257)

At present, fifteen kinds of traditional Chinese medicines such as scutellaria baicalensis, rhubarb, astragalus, phellodendron, coptis, burnet, rehmannia glutinosa, angelica dahurica, Baiwei, bletilla striata, angelica, comfrey, frankincense, myrrh, and borneol have not been made into preparations for the preparation of treatment. Relevant reports on medicines for third-degree burns and scalds

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