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A kind of chitosan composite gel foam agent suitable for female barrier spermicidal double contraceptive effect and preparation method thereof

A composite gel and chitosan technology, applied in the direction of medical preparations containing active ingredients, diseases, antifungal agents, etc., can solve problems such as inconvenient use, damaged vaginal friction, and vaginal condoms affecting the quality of sexual life

Active Publication Date: 2014-10-22
广东同德药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

According to scientific experiments, the use of vaginal condoms can reduce the chance of women being infected by HIV by more than 90%. However, the use of vaginal condoms affects the quality of sexual life, and creates a diaphragm shape. Improper materials can easily cause vaginal friction damage, and there are Allergies in some women
[0005] Others, female barrier contraceptives such as: Some suppositories and films are inconvenient to use during sexual activities, such as waiting for 5 minutes for each sexual intercourse

Method used

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  • A kind of chitosan composite gel foam agent suitable for female barrier spermicidal double contraceptive effect and preparation method thereof
  • A kind of chitosan composite gel foam agent suitable for female barrier spermicidal double contraceptive effect and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] （1） prescription composition

[0030] Chitosan 10% (W / W

[0031] Carbomer 1% (W / W)

[0032] Octoxynol 1% (W / W)

[0033] Tween-80 1% (W / W)

[0034] Borneol 1% (W / W)

[0035] Menthol 1% (W / W)

[0036] Citric acid 0.5 % (W / W)

[0037] SLS 1% (W / W)

[0038] Stearic Acid 0.5% (W / W)

[0039] Glycerol 5 % (W / W)

[0040] Citrate buffer to make up to 100g

[0041] (2) Preparation method

[0042] Dissolve the prescribed amount of chitosan and carbomer in a certain amount of citric acid buffer, stir and heat at 80°C to dissolve completely, add the prescribed amount of octoxynol ether, and Tween-80 to obtain solution A, and set aside. The prescribed amount of borneol, menthol, and stearic acid are dissolved in the prescribed amount of glycerin, fully dissolved, filtered to obtain B liquid, and set aside. Add liquid B to liquid A and mix thoroughly, add citric acid and SLS, make up the buffer to the required weight, adjust its pH value to 4.5 and homogenize under...

Embodiment 2

[0044] （1） prescription composition

[0045] Chitosan 5% (W / W)

[0046] Carbomer 3% (W / W)

[0047] Nonoxynol 2% (W / W)

[0048] Tween-80 2% (W / W)

[0049]Borneol 2% (W / W)

[0050] Menthol 5% (W / W)

[0051] Lactic Acid 1% (W / W)

[0052] SLS 0.5% (W / W)

[0053] Stearic Acid 1% (W / W)

[0054] Propylene Glycol 10% (W / W)

[0055] Citrate buffer to make up to 100g

[0056] (2) Preparation method: refer to Example 1

Embodiment 3

[0058] （1） prescription composition

[0059] Chitosan 10% (W / W

[0060] Carbomer 1% (W / W)

[0061] Nonoxynol 1% (W / W)

[0062] Tween-80 5% (W / W)

[0063] Borneol 1% (W / W)

[0064] Menthol 3% (W / W)

[0065] Lactic Acid 2% (W / W)

[0066] SLS 1% (W / W)

[0067] Stearic Acid 1% (W / W)

[0068] Propylene Glycol 10% (W / W)

[0069] (2) Preparation method: refer to Example 1

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Abstract

The invention relates to a chitosan plural gel foaming agent suitable for a female sperm shielding and killing dual-contraception effect and a preparation method thereof, and belongs to the technical field of foaming agent production. The chitosan plural gel foaming agent suitable for the female sperm shielding and killing dual-contraception effect has a dual-contraception effect of vagina shielding and vagina sperm killing, and meanwhile has a fungal-infection-resistant effect. The foaming agent forms a medicament liquid by consisting of a matrix, a surface active agent, an auxiliary medicament, a cosolvent, an acidifier, a foaming agent, a foam stabilizing agent and a solvent, and the foaming agent and a propellent form a plural gel foaming agent according to the weight proportion of (100:10) to 20. The preparation method comprises the following steps: dissolving chitosan and carbomer into a citrate buffer solution with a certain amount; blending, heating to 80 DEG C to dissolve completely, adding the surface active agent so as to obtain a solution A; dissolving borneol, menthol crystal and stearic acid into glycerol, dissolving fully, and filtering so as to obtain a solution B; adding the solution B into the solution A, mixing fully, adding citric acid and SLS (sodium lauryl sulfate), supplying the buffer solution to the required weight, carrying out vacuum homogenizing for 2 hours, thereby obtaining the gel foaming preparation, and then adding the propellent.

Description

technical field [0001] The invention relates to a chitosan composite gel foaming agent suitable for female barrier spermicidal double contraceptive effect and a preparation method thereof, in particular to a double contraceptive effect suitable for female vaginal barrier and vaginal sperm killing, and has The invention relates to a chitosan composite gel foam preparation with anti-fungal infection effect, which belongs to the technical field of gel foam production. Background technique [0002] Female barrier contraception refers to the use of physical methods (mechanical barriers) to prevent sperm from reaching the cervix, or the use of chemical agents to inactivate sperm in the vagina. The two can also be combined to block the combination of sperm and egg to achieve the purpose of contraception. Among the large families of modern contraceptives, barrier contraception is particularly attractive because of its dual functions of contraception and prevention of sexually trans...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/722A61K36/534A61K31/045A61K9/12A61P15/18A61P15/02A61P31/10
Inventor 王一飞万来鸿林青霞林柳清
Owner 广东同德药业有限公司
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